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- 1180种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；
- 靶点包括TGFβ、TNFα、MMP、EGFR、NADPH-oxidase等；
- 部分化合物已经得到FDA批准上市；?
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
抗纤维化化合物库
Anti-Fibrosis Compound Library
纤维化（fibrosis）是一种病理改变，主要表现为器官组织内纤维结缔组织增多，实质细胞减少，持续进展可致器官结构破坏和功能减退，乃至衰竭，严重威胁人类健康和生命。纤维化可发生于多种器官，常见的包括肺脏、肝脏、肾脏、骨髓等。纤维化通常由各种刺激导致的慢性炎症性反应引起，包括：持续性感染，自身免疫反应，过敏性反应，化学刺激，射线和组织损伤等。 TargetMol 抗纤维化化合物库收集了1180 种潜在的抗纤维化分子，包括相关靶点如TGFβ、TNFα、MMP 的抑制剂、抗氧化剂及抗炎分子等，是研究纤维化机制和开发抗纤维化药物的良好工具。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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化合物库相关信息
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抗纤维化化合物库规格
- 1 mg
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品特性
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
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化合物库组成
Apoptosis
Apoptosis
Apoptosis
Apoptosis
Apoptosis
Autophagy
Autophagy
Autophagy
Autophagy
Autophagy
Reactive Oxygen Species
Reactive Oxygen Species
Reactive Oxygen Species
Reactive Oxygen Species
Reactive Oxygen Species
Endogenous Metabolite
Endogenous Metabolite
Endogenous Metabolite
Endogenous Metabolite
Endogenous Metabolite
COX
COX
COX
COX
COX
VEGFR
VEGFR
VEGFR
VEGFR
VEGFR
Antibacterial
Antibacterial
Antibacterial
Antibacterial
Antibacterial
MMP
MMP
MMP
MMP
MMP
Antioxidant
Antioxidant
Antioxidant
Antioxidant
Antioxidant
NF-κB
NF-κB
NF-κB
NF-κB
NF-κB
TNF
TNF
TNF
TNF
TNF
TGF-beta/Smad
TGF-beta/Smad
TGF-beta/Smad
TGF-beta/Smad
TGF-beta/Smad
FGFR
FGFR
FGFR
FGFR
FGFR
PDGFR
PDGFR
PDGFR
PDGFR
PDGFR
Wnt/beta-catenin
Wnt/beta-catenin
Wnt/beta-catenin
Wnt/beta-catenin
Wnt/beta-catenin
ROS
ROS
ROS
ROS
ROS
c-Kit
IL Receptor
c-Kit
IL Receptor
c-Kit
IL Receptor
c-Kit
IL Receptor
c-Kit
IL Receptor
FLT
FLT
FLT
FLT
FLT
Antifungal
Parasite
Antifungal
Parasite
Antifungal
Parasite
Antifungal
Parasite
Antifungal
Parasite
Influenza Virus
Influenza Virus
Influenza Virus
Influenza Virus
Influenza Virus
ALK
ALK
ALK
ALK
ALK
EGFR
EGFR
EGFR
EGFR
EGFR
Glucocorticoid Receptor
Glucocorticoid Receptor
Glucocorticoid Receptor
Glucocorticoid Receptor
Glucocorticoid Receptor
JAK
Antibiotic
STAT
Antibiotic
JAK
STAT
Antibiotic
JAK
STAT
Antibiotic
JAK
STAT
Antibiotic
JAK
STAT
Ferroptosis
NADPH
Ferroptosis
NADPH
Ferroptosis
NADPH
Ferroptosis
NADPH
Ferroptosis
NADPH
p38 MAPK
ERK
p38 MAPK
ERK
ERK
p38 MAPK
ERK
p38 MAPK
ERK
p38 MAPK
P450
Src
NO Synthase
P450
Src
NO Synthase
NO Synthase
P450
Src
P450
NO Synthase
Src
P450
Src
NO Synthase
HIV Protease
Cannabinoid Receptor
Cannabinoid Receptor
HIV Protease
Cannabinoid Receptor
HIV Protease
Cannabinoid Receptor
HIV Protease
Cannabinoid Receptor
HIV Protease
c-Met/HGFR
PPAR
c-Met/HGFR
PPAR
c-Met/HGFR
PPAR
c-Met/HGFR
PPAR
c-Met/HGFR
PPAR
CFTR
CFTR
CFTR
CFTR
CFTR
Mitophagy
Virus Protease
Nrf2
Mitophagy
Virus Protease
Nrf2
Mitophagy
Nrf2
Virus Protease
Mitophagy
Nrf2
Virus Protease
Mitophagy
Nrf2
Virus Protease
Caspase
DNA/RNA Synthesis
Caspase
DNA/RNA Synthesis
DNA/RNA Synthesis
Caspase
Caspase
DNA/RNA Synthesis
Caspase
DNA/RNA Synthesis
AMPK
Bcr-Abl
c-RET
Interleukin
NOS
AMPK
Bcr-Abl
c-RET
Interleukin
NOS
AMPK
Bcr-Abl
c-RET
NOS
Interleukin
AMPK
Bcr-Abl
c-RET
Interleukin
NOS
AMPK
Bcr-Abl
c-RET
Interleukin
NOS
Akt
Calcium Channel
PDE
Lipoxygenase
PARP
Akt
Calcium Channel
Lipoxygenase
PARP
PDE
Akt
Calcium Channel
Lipoxygenase
PDE
PARP
Akt
Calcium Channel
Lipoxygenase
PDE
PARP
Akt
Calcium Channel
Lipoxygenase
PDE
PARP
BCL
Mitochondrial Metabolism
Prostaglandin Receptor
Tyrosinase
PI3K
PKC
BCL
Mitochondrial Metabolism
Prostaglandin Receptor
Tyrosinase
PI3K
PKC
BCL
Mitochondrial Metabolism
Prostaglandin Receptor
PI3K
PKC
Tyrosinase
BCL
Mitochondrial Metabolism
Prostaglandin Receptor
PKC
PI3K
Tyrosinase
BCL
Mitochondrial Metabolism
Prostaglandin Receptor
PI3K
PKC
Tyrosinase
CDK
JNK
Anti-infection
Aurora Kinase
Tyrosine Kinases
Aurora Kinase
CDK
Anti-infection
JNK
Tyrosine Kinases
Aurora Kinase
Anti-infection
CDK
JNK
Tyrosine Kinases
Anti-infection
Aurora Kinase
CDK
JNK
Tyrosine Kinases
Anti-infection
Aurora Kinase
CDK
JNK
Tyrosine Kinases
GABA Receptor
HIF/HIF Prolyl-Hydroxylase
Trk receptor
Estrogen/progestogen Receptor
Raf
TLR
ROS Kinase
GABA Receptor
HIF/HIF Prolyl-Hydroxylase
Estrogen/progestogen Receptor
Raf
Trk receptor
TLR
ROS Kinase
GABA Receptor
Estrogen/progestogen Receptor
Trk receptor
ROS Kinase
TLR
HIF/HIF Prolyl-Hydroxylase
Raf
GABA Receptor
HIF/HIF Prolyl-Hydroxylase
Estrogen/progestogen Receptor
Raf
Trk receptor
ROS Kinase
TLR
GABA Receptor
HIF/HIF Prolyl-Hydroxylase
Estrogen/progestogen Receptor
Raf
Trk receptor
ROS Kinase
TLR
IκB/IKK
Dehydrogenase
Potassium Channel
Topoisomerase
SARS-CoV
Dehydrogenase
IκB/IKK
Potassium Channel
Topoisomerase
SARS-CoV
Dehydrogenase
Potassium Channel
Topoisomerase
SARS-CoV
IκB/IKK
Dehydrogenase
IκB/IKK
Potassium Channel
Topoisomerase
SARS-CoV
Dehydrogenase
IκB/IKK
Potassium Channel
Topoisomerase
SARS-CoV
c-Fms
LPA Receptor
P-gp
AChE
Beta Amyloid
NOD-like Receptor (NLR)
Phospholipase
HSV
NADPH-oxidase
Adrenergic Receptor
HER
Xanthine Oxidase
TRP/TRPV Channel
AChE
c-Fms
Adrenergic Receptor
Beta Amyloid
LPA Receptor
HSV
P-gp
NOD-like Receptor (NLR)
NADPH-oxidase
Phospholipase
HER
TRP/TRPV Channel
Xanthine Oxidase
AChE
Adrenergic Receptor
Beta Amyloid
c-Fms
LPA Receptor
HSV
HER
P-gp
NADPH-oxidase
NOD-like Receptor (NLR)
Phospholipase
TRP/TRPV Channel
Xanthine Oxidase
AChE
Adrenergic Receptor
Beta Amyloid
c-Fms
LPA Receptor
HSV
HER
P-gp
NADPH-oxidase
NOD-like Receptor (NLR)
Phospholipase
TRP/TRPV Channel
Xanthine Oxidase
AChE
Beta Amyloid
Adrenergic Receptor
c-Fms
LPA Receptor
HSV
HER
P-gp
NADPH-oxidase
NOD-like Receptor (NLR)
Phospholipase
TRP/TRPV Channel
Xanthine Oxidase
CCR
Glutathione Peroxidase
Antiviral
5-HT Receptor
CSF-1R
Adenosine Receptor
LPL Receptor
S6 Kinase
Syk
PKA
Sodium Channel
ATPase
Estrogen Receptor/ERR
Immunology/Inflammation related
TAM Receptor
Adenosine Receptor
5-HT Receptor
CCR
Antiviral
CSF-1R
Glutathione Peroxidase
ATPase
Immunology/Inflammation related
LPL Receptor
PKA
Estrogen Receptor/ERR
Syk
Sodium Channel
S6 Kinase
TAM Receptor
Adenosine Receptor
5-HT Receptor
Antiviral
CCR
ATPase
CSF-1R
Glutathione Peroxidase
Estrogen Receptor/ERR
Immunology/Inflammation related
LPL Receptor
PKA
S6 Kinase
Sodium Channel
TAM Receptor
Syk
Adenosine Receptor
5-HT Receptor
Antiviral
CCR
CSF-1R
ATPase
Glutathione Peroxidase
Estrogen Receptor/ERR
Immunology/Inflammation related
LPL Receptor
PKA
Syk
S6 Kinase
TAM Receptor
Sodium Channel
Adenosine Receptor
5-HT Receptor
Antiviral
CCR
CSF-1R
ATPase
Glutathione Peroxidase
Estrogen Receptor/ERR
Immunology/Inflammation related
LPL Receptor
PKA
Syk
S6 Kinase
Sodium Channel
TAM Receptor
AChR
HIF
Drug Metabolite
Free radical scavengers
HDAC
Histamine Receptor
Cysteine Protease
Chk
GSK-3
MAPK
NOD
Reductase
Epigenetic Reader Domain
MEK
PGE Synthase
AChR
Drug Metabolite
Chk
HIF
Cysteine Protease
Free radical scavengers
HDAC
Histamine Receptor
GSK-3
MAPK
Epigenetic Reader Domain
NOD
Reductase
MEK
PGE Synthase
AChR
Chk
Drug Metabolite
Cysteine Protease
Epigenetic Reader Domain
HIF
GSK-3
Free radical scavengers
HDAC
Histamine Receptor
MEK
NOD
PGE Synthase
Reductase
MAPK
AChR
Chk
Drug Metabolite
Cysteine Protease
Epigenetic Reader Domain
HIF
GSK-3
Free radical scavengers
HDAC
Histamine Receptor
MAPK
MEK
NOD
PGE Synthase
Reductase
AChR
Chk
Cysteine Protease
Drug Metabolite
GSK-3
HIF
Epigenetic Reader Domain
Free radical scavengers
HDAC
Histamine Receptor
MAPK
MEK
NOD
PGE Synthase
Reductase
Ephrin Receptor
Casein Kinase
Chloride channel
Glucosidase
GPR
Annexin A
Monoamine Oxidase
FAAH
Ligand for E3 Ligase
RAAS
Reverse Transcriptase
Serine Protease
Serine/threonin kinase
UGT
Molecular Glues
ribosome
HSP
Phosphatase
HCV Protease
mTOR
PDK
Retinoid Receptor
Sirtuin
Annexin A
Ephrin Receptor
Casein Kinase
Chloride channel
Monoamine Oxidase
Glucosidase
GPR
HSP
FAAH
Molecular Glues
Ligand for E3 Ligase
ribosome
HCV Protease
RAAS
Phosphatase
Reverse Transcriptase
Serine Protease
Serine/threonin kinase
mTOR
UGT
Sirtuin
PDK
Retinoid Receptor
Casein Kinase
Chloride channel
Annexin A
Ephrin Receptor
Glucosidase
GPR
FAAH
HCV Protease
HSP
Ligand for E3 Ligase
Monoamine Oxidase
Molecular Glues
mTOR
Phosphatase
RAAS
Reverse Transcriptase
Serine Protease
Serine/threonin kinase
PDK
ribosome
Sirtuin
UGT
Retinoid Receptor
Annexin A
Casein Kinase
Chloride channel
Ephrin Receptor
Glucosidase
GPR
FAAH
HCV Protease
HSP
Monoamine Oxidase
Ligand for E3 Ligase
Molecular Glues
mTOR
RAAS
PDK
Phosphatase
Reverse Transcriptase
Serine Protease
Serine/threonin kinase
Retinoid Receptor
ribosome
UGT
Sirtuin
Annexin A
Casein Kinase
Chloride channel
Ephrin Receptor
Glucosidase
GPR
FAAH
HSP
Ligand for E3 Ligase
HCV Protease
Monoamine Oxidase
Molecular Glues
RAAS
Phosphatase
mTOR
Reverse Transcriptase
Serine Protease
Serine/threonin kinase
ribosome
PDK
Sirtuin
UGT
Retinoid Receptor
CXCR
Discoidin Domain Receptor (DDR)
Hedgehog/Smoothened
Aromatase
Gamma-secretase
Gap Junction Protein
Integrin
FAK
IAP
ADC Cytotoxin
BACE
Lipase
MAO
Porcupine
ROR
Aminopeptidase
Antifection
Epoxide Hydrolase
HBV
MLK
Opioid Receptor
RIP kinase
Microtubule Associated
MRP
P2X Receptor
p53
Smo
Tie-2
Histone Acetyltransferase
Histone Methyltransferase
Indoleamine 2,3-Dioxygenase (IDO)
IRE1
DNA gyrase
IGF-1R
LTR
Proteasome
RSV
Leukotriene Receptor
PAI-1
PTEN
Aminopeptidase
Antifection
ADC Cytotoxin
BACE
CXCR
Aromatase
Discoidin Domain Receptor (DDR)
FAK
Hedgehog/Smoothened
Lipase
MAO
DNA gyrase
Epoxide Hydrolase
IAP
Gamma-secretase
Gap Junction Protein
Histone Acetyltransferase
Histone Methyltransferase
Microtubule Associated
MRP
Indoleamine 2,3-Dioxygenase (IDO)
IRE1
P2X Receptor
p53
HBV
IGF-1R
Porcupine
Integrin
LTR
ROR
MLK
Smo
Tie-2
Opioid Receptor
Leukotriene Receptor
RIP kinase
Proteasome
RSV
PAI-1
PTEN
Aminopeptidase
Antifection
ADC Cytotoxin
Aromatase
BACE
CXCR
Discoidin Domain Receptor (DDR)
DNA gyrase
Epoxide Hydrolase
Gamma-secretase
Gap Junction Protein
Hedgehog/Smoothened
Lipase
MAO
HBV
IGF-1R
Histone Acetyltransferase
Histone Methyltransferase
Integrin
LTR
Indoleamine 2,3-Dioxygenase (IDO)
IRE1
MLK
Leukotriene Receptor
Opioid Receptor
Porcupine
ROR
Proteasome
RIP kinase
PAI-1
RSV
PTEN
Smo
Tie-2
FAK
IAP
Microtubule Associated
MRP
P2X Receptor
p53
Aminopeptidase
Antifection
ADC Cytotoxin
Aromatase
BACE
CXCR
Discoidin Domain Receptor (DDR)
DNA gyrase
Epoxide Hydrolase
FAK
Gamma-secretase
Gap Junction Protein
Hedgehog/Smoothened
Lipase
MAO
HBV
IGF-1R
IAP
Histone Acetyltransferase
Histone Methyltransferase
Integrin
LTR
Microtubule Associated
MRP
Indoleamine 2,3-Dioxygenase (IDO)
IRE1
MLK
Leukotriene Receptor
Porcupine
P2X Receptor
p53
Opioid Receptor
ROR
PAI-1
RIP kinase
PTEN
Proteasome
RSV
Smo
Tie-2
Aminopeptidase
Antifection
ADC Cytotoxin
Aromatase
BACE
CXCR
Discoidin Domain Receptor (DDR)
Epoxide Hydrolase
FAK
Gamma-secretase
Gap Junction Protein
DNA gyrase
Hedgehog/Smoothened
HBV
IGF-1R
IAP
Lipase
MAO
Histone Acetyltransferase
Histone Methyltransferase
Integrin
Microtubule Associated
MRP
LTR
Indoleamine 2,3-Dioxygenase (IDO)
IRE1
MLK
P2X Receptor
p53
Opioid Receptor
Leukotriene Receptor
Porcupine
ROR
RIP kinase
Proteasome
PAI-1
RSV
Smo
Tie-2
PTEN
CaSR
cell cycle arrest
DNA
Galectin
HMG-CoA Reductase
Guanylate cyclase
Anion Exchanger
ASK
ATP Citrate Lyase
c-Myc
IRAK
Adiponectin receptor
Amino Acids and Derivatives
Amylase
Carbonic Anhydrase
Glutathione reductase
hCE
IFNAR
LDL
PAK
Progesterone Receptor
Proton pump
Rho
Survivin
Androgen Receptor
ATM/ATR
BTK
Dynamin
E1/E2/E3 Enzyme
advanced glycation end products
CaMK
DNA Methyltransferase
Somatostatin
Telomerase
MyD88
RANKL/RANK
ROCK
RAR/RXR
Transferase
transporter
Hydroxylase
Liver X Receptor
AAK1 (AP2 associated kinase 1)
FLAP
GST
Monocarboxylate transporter
PAD
Pyroptosis
Hck
Hydrogenase
iGluR
Melatonin Receptor
N-Acetylglucosaminyltransferase
OXPHOS
Phosphorylase
Platelet aggregation
PLK
Ras
SGLT
Thrombin
Androgen Receptor
Anion Exchanger
advanced glycation end products
Adiponectin receptor
Amino Acids and Derivatives
Amylase
ASK
ATP Citrate Lyase
Carbonic Anhydrase
CaSR
cell cycle arrest
AAK1 (AP2 associated kinase 1)
ATM/ATR
c-Myc
DNA
Galectin
BTK
CaMK
HMG-CoA Reductase
Dynamin
E1/E2/E3 Enzyme
Glutathione reductase
hCE
LDL
IFNAR
DNA Methyltransferase
IRAK
Guanylate cyclase
MyD88
PAK
Hydroxylase
Progesterone Receptor
Proton pump
Rho
Liver X Receptor
RANKL/RANK
FLAP
Survivin
RAR/RXR
ROCK
GST
Hck
Monocarboxylate transporter
Hydrogenase
iGluR
Transferase
transporter
Melatonin Receptor
PAD
Somatostatin
Telomerase
N-Acetylglucosaminyltransferase
Pyroptosis
OXPHOS
Phosphorylase
Platelet aggregation
PLK
Ras
SGLT
Thrombin
advanced glycation end products
Androgen Receptor
Adiponectin receptor
Amino Acids and Derivatives
Amylase
AAK1 (AP2 associated kinase 1)
Carbonic Anhydrase
CaSR
cell cycle arrest
ATM/ATR
Anion Exchanger
CaMK
DNA
BTK
DNA Methyltransferase
Galectin
Dynamin
E1/E2/E3 Enzyme
Guanylate cyclase
FLAP
HMG-CoA Reductase
Glutathione reductase
hCE
GST
Hck
LDL
IFNAR
Hydrogenase
iGluR
Hydroxylase
PAK
Melatonin Receptor
Monocarboxylate transporter
Liver X Receptor
Progesterone Receptor
Proton pump
Rho
N-Acetylglucosaminyltransferase
PAD
Survivin
Pyroptosis
Somatostatin
Telomerase
OXPHOS
RAR/RXR
Phosphorylase
Platelet aggregation
PLK
Ras
SGLT
Transferase
transporter
Thrombin
ASK
ATP Citrate Lyase
c-Myc
IRAK
MyD88
RANKL/RANK
ROCK
Androgen Receptor
advanced glycation end products
Anion Exchanger
Adiponectin receptor
Amino Acids and Derivatives
Amylase
ASK
ATP Citrate Lyase
Carbonic Anhydrase
AAK1 (AP2 associated kinase 1)
ATM/ATR
CaSR
cell cycle arrest
DNA
CaMK
c-Myc
BTK
Galectin
DNA Methyltransferase
Guanylate cyclase
Dynamin
E1/E2/E3 Enzyme
FLAP
HMG-CoA Reductase
Glutathione reductase
hCE
GST
Hck
LDL
IRAK
IFNAR
Hydrogenase
iGluR
MyD88
Hydroxylase
PAK
Melatonin Receptor
Progesterone Receptor
Proton pump
Rho
Monocarboxylate transporter
Liver X Receptor
N-Acetylglucosaminyltransferase
Survivin
RANKL/RANK
OXPHOS
PAD
ROCK
Somatostatin
Telomerase
Phosphorylase
Platelet aggregation
PLK
Ras
Pyroptosis
RAR/RXR
SGLT
Thrombin
Transferase
transporter
Androgen Receptor
advanced glycation end products
Anion Exchanger
Adiponectin receptor
Amino Acids and Derivatives
Amylase
ATM/ATR
Carbonic Anhydrase
ASK
ATP Citrate Lyase
CaSR
cell cycle arrest
AAK1 (AP2 associated kinase 1)
BTK
CaMK
c-Myc
DNA
Dynamin
E1/E2/E3 Enzyme
DNA Methyltransferase
Galectin
Guanylate cyclase
HMG-CoA Reductase
FLAP
Glutathione reductase
hCE
IRAK
LDL
GST
Hck
IFNAR
MyD88
Hydroxylase
Hydrogenase
iGluR
Monocarboxylate transporter
PAK
Liver X Receptor
Melatonin Receptor
RANKL/RANK
Progesterone Receptor
Proton pump
Rho
PAD
ROCK
N-Acetylglucosaminyltransferase
Survivin
Somatostatin
Telomerase
Pyroptosis
RAR/RXR
OXPHOS
Phosphorylase
Platelet aggregation
PLK
Ras
Transferase
transporter
SGLT
Thrombin
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