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Anti-CD71 Monoclonal Antibody-AF488
产品编号 TMAZ-0133A4
别名 Transferrin receptor protein 1, p90, T9
Anti-CD71 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-CD71 Monoclonal Antibody-AF488
Anti-CD71 Monoclonal Antibody-AF488
产品编号 TMAZ-0133A4 别名 Transferrin receptor protein 1, p90, T9
Anti-CD71 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | 询价 | 7日内发货 | |
| 100 μg | 询价 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
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| 产品描述 | Anti-CD71 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| 别名 | Transferrin receptor protein 1, p90, T9 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of Jurkat cells with TMAZ-0133A4BI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD71 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed: 26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed: 26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed: 26214738). When dietary levels of stearate (C18: 0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed: 26214738). When dietary levels of stearate (C18: 0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed: 26214738)|(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus |
| 偶联 | AF488 |
| 其他可选修饰符 | Biotin/APC/PE/AF555/AF647 |
| 可提供抗体种类 | 3 |
| 免疫原 | CD71 |
| 抗原种属 | Human |
| 基因ID | 7037 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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