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Anti-CLU Monoclonal Antibody-PE
产品编号 TMAZ-0178P
别名 Clusterin, Testosterone-repressed prostate message 2, Ku70-binding protein 1, Complement cytolysis inhibitor, Sulfated glycoprotein 2, Aging-associated gene 4 protein, NA1/NA2, Apolipoprotein J, Complement-associated protein SP-40,40
Anti-CLU Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-PE can be used in ELISA, FACS, IF.
Anti-CLU Monoclonal Antibody-PE
Anti-CLU Monoclonal Antibody-PE
产品编号 TMAZ-0178P 别名 Clusterin, Testosterone-repressed prostate message 2, Ku70-binding protein 1, Complement cytolysis inhibitor, Sulfated glycoprotein 2, Aging-associated gene 4 protein, NA1/NA2, Apolipoprotein J, Complement-associated protein SP-40,40
Anti-CLU Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-PE can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | 询价 | 7日内发货 | |
| 100 μg | 询价 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
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| 产品描述 | Anti-CLU Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-PE can be used in ELISA, FACS, IF. |
| 别名 | Clusterin, Testosterone-repressed prostate message 2, Ku70-binding protein 1, Complement cytolysis inhibitor, Sulfated glycoprotein 2, Aging-associated gene 4 protein, NA1/NA2, Apolipoprotein J, Complement-associated protein SP-40,40 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CLU overexpressed 355F cells with TMAZ-0178P, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CLU protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed: 11123922, PubMed: 19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed: 11123922, PubMed: 12176985, PubMed: 17260971, PubMed: 19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed: 12047389, PubMed: 17407782, PubMed: 17412999). Does not require ATP (PubMed: 11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed: 11123922). Does not refold proteins by itself (PubMed: 11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed: 21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed: 2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed: 20068069). Modulates NF-kappa-B transcriptional activity (PubMed: 12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed: 16113678, PubMed: 17689225). Plays a role in the regulation of cell proliferation (PubMed: 19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed: 22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed: 21567405) |
| 偶联 | PE |
| 其他可选修饰符 | Biotin/APC/AF488/AF555/AF647 |
| 可提供抗体种类 | 3 |
| 免疫原 | CLU |
| 抗原种属 | Human |
| 基因ID | 1191 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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