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Anti-IL13 Monoclonal Antibody-AF647
产品编号 TMAZ-0022A6
Anti-IL13 Monoclonal Antibody-AF647 is a Biotin-conjugated humanized rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
Anti-IL13 Monoclonal Antibody-AF647
Anti-IL13 Monoclonal Antibody-AF647
产品编号 TMAZ-0022A6
Anti-IL13 Monoclonal Antibody-AF647 is a Biotin-conjugated humanized rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | 询价 | 7日内发货 | |
| 100 μg | 询价 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-IL13 Monoclonal Antibody-AF647 is a Biotin-conjugated humanized rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF. |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of IL13 overexpressed 382F cells with TMAZ-0022A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL13 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | Greater than 95%, as determined by SDS-PAGE. |
| 研究背景 | Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed: 8096327, PubMed: 8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed: 8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed: 7903680, PubMed: 8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed: 8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed: 9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed: 21622864) |
| 偶联 | AF647 |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF55 |
| 可提供抗体种类 | 2 |
| 免疫原 | IL13 |
| 抗原种属 | Human |
| 基因ID | 3596 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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