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Anti-NPC2 Monoclonal Antibody-PE
产品编号 TMAZ-0065P
别名 NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Epididymal secretory protein E1, Human epididymis-specific protein 1
Anti-NPC2 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody-PE can be used in ELISA, FACS.
Anti-NPC2 Monoclonal Antibody-PE
Anti-NPC2 Monoclonal Antibody-PE
产品编号 TMAZ-0065P 别名 NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Epididymal secretory protein E1, Human epididymis-specific protein 1
Anti-NPC2 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody-PE can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | 询价 | 7日内发货 | |
| 100 μg | 询价 | 7日内发货 |
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| 产品描述 | Anti-NPC2 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody-PE can be used in ELISA, FACS. |
| 别名 | NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Epididymal secretory protein E1, Human epididymis-specific protein 1 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of NPC2 overexpressed 476F cells with TMAZ-0065P, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of NPC2 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed: 11125141, PubMed: 15937921, PubMed: 17018531, PubMed: 18772377, PubMed: 29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed: 17018531, PubMed: 18772377, PubMed: 27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed: 18823126). NPC2 binds cholesterol with a 1: 1 stoichiometry (PubMed: 17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed: 17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity) |
| 偶联 | PE |
| 其他可选修饰符 | Biotin/APC/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | NPC2 |
| 抗原种属 | Human |
| 基因ID | 10577 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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