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Anti-PDGFRB Monoclonal Antibody-AF488
产品编号 TMAZ-0120A4
别名 Beta-type platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1, CD140 antigen-like family member B
Anti-PDGFRB Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting PDGFRB. Anti-PDGFRB Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-PDGFRB Monoclonal Antibody-AF488
Anti-PDGFRB Monoclonal Antibody-AF488
产品编号 TMAZ-0120A4 别名 Beta-type platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1, CD140 antigen-like family member B
Anti-PDGFRB Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting PDGFRB. Anti-PDGFRB Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | 询价 | 7日内发货 | |
| 100 μg | 询价 | 7日内发货 |
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产品介绍
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偶联与修饰
抗原信息
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| 产品描述 | Anti-PDGFRB Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting PDGFRB. Anti-PDGFRB Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| 别名 | Beta-type platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1, CD140 antigen-like family member B |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of PDGFRB overexpressed 336F cells with TMAZ-0120A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PDGFRB protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor |
| 偶联 | AF488 |
| 其他可选修饰符 | Biotin/APC/PE/AF555/AF647 |
| 可提供抗体种类 | 3 |
| 免疫原 | PDGFRB |
| 抗原种属 | Human |
| 基因ID | 5159 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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