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Anti-PODXL Monoclonal Antibody-PE
产品编号 TMAZ-0170P
别名 GCTM-2 antigen, Podocalyxin-like protein 1, Podocalyxin, Gp200
Anti-PODXL Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting PODXL. Anti-PODXL Monoclonal Antibody-PE can be used in ELISA, FACS.
Anti-PODXL Monoclonal Antibody-PE
Anti-PODXL Monoclonal Antibody-PE
产品编号 TMAZ-0170P 别名 GCTM-2 antigen, Podocalyxin-like protein 1, Podocalyxin, Gp200
Anti-PODXL Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting PODXL. Anti-PODXL Monoclonal Antibody-PE can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | 询价 | 7日内发货 | |
| 100 μg | 询价 | 7日内发货 |
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产品介绍
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偶联与修饰
抗原信息
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| 产品描述 | Anti-PODXL Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting PODXL. Anti-PODXL Monoclonal Antibody-PE can be used in ELISA, FACS. |
| 别名 | GCTM-2 antigen, Podocalyxin-like protein 1, Podocalyxin, Gp200 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of PODXL overexpressed 377F cells with TMAZ-0170P, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PODXL protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells |
| 偶联 | PE |
| 其他可选修饰符 | Biotin/APC/AF488/AF555/AF647 |
| 可提供抗体种类 | 2 |
| 免疫原 | PODXL |
| 抗原种属 | Human |
| 基因ID | 5420 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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