购物车
- 全部删除
- 您的购物车当前为空
Enoticumab(REGN421,SAR153192)是一种针对人类Dll4的IgG1κ类型抗体。DLL4为Notch信号通路中的关键配体,其功能通过巨胞饮作用依赖的非转录调控机制影响长链脂肪酸的摄取。该抗体在卵巢癌异种移植模型中展示出明确的体内活性,其中EGN421(2.5mg/kg,周剂量)在小鼠皮下TOV-112D及腹膜内A2780人类肿瘤异种移植模型中实现了分别达到86%和83%的肿瘤生长抑制效果。
Enoticumab(REGN421,SAR153192)是一种针对人类Dll4的IgG1κ类型抗体。DLL4为Notch信号通路中的关键配体,其功能通过巨胞饮作用依赖的非转录调控机制影响长链脂肪酸的摄取。该抗体在卵巢癌异种移植模型中展示出明确的体内活性,其中EGN421(2.5mg/kg,周剂量)在小鼠皮下TOV-112D及腹膜内A2780人类肿瘤异种移植模型中实现了分别达到86%和83%的肿瘤生长抑制效果。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 3,600 | 5日内发货 | |
5 mg | ¥ 10,800 | 5日内发货 |
产品描述 | Enoticumab (REGN421, SAR153192) is an IgG1κ antibody that specifically targets human Delta-like ligand 4 (Dll4), which serves as a crucial component of the Notch signaling pathway and regulates the uptake of fatty acids through non-transcriptional modulation of macropinocytosis-dependent long-chain fatty acid absorption. Demonstrated efficacy in vivo, Enoticumab was shown to inhibit tumor growth by 86% and 83% in subcutaneous TOV-112D and intraperitoneal A2780 human ovarian tumor xenograft mouse models, respectively, when administered at a dose of 2.5 mg/kg weekly [1]. |
别名 | REGN421 |
CAS No. | 1192578-27-0 |
存储 | Shipping with blue ice. |
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.