PSMA-IN-2

产品编号 T87271Cas号 2946600-14-0

PSMA-IN-2 是 PSMA 的抑制剂，其 Ki 值为 1.07 nM。PSMA-IN-2 显示出良好的 in vivo 近红外成像 (λEM = 1088 nm, λex = 808 nm)，可用于 PSMA 阳性肿瘤小鼠的近红外 II 成像引导的肿瘤切除手术。

产品编号 T87271Cas号 2946600-14-0

规格	价格	库存	数量
10 mg	询价	待询
50 mg	询价	待询

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生物活性

产品描述	PSMA-IN-2, an inhibitor of PSMA with a K i value of 1.07 nM, exhibits favorable in vivo NIR imaging (λ EM = 1088 nm, λ ex = 808 nm) and is useful for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice [1].
靶点活性	PSMA:1.07 nM (Ki)
体内活性	PSMA-IN-2 (compound 24) (0.85 mg/kg, i.v., 24 h) is confirmed by NIR-II imaging to bind specifically to PSMA in vivo [1]. In 22Rv1 xenograft models [1], following an intravenous injection at a dosage of 0.85 mg/kg, the compound was excreted from the blood pool, leading to increased signal intensity in 22Rv1 xenografts over time as the background signal weakened under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms), with inhibition ranging from 38% to 52% based on semi-quantitative data DCFPyL in tumors.