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SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) 是高选择性非竞争性 mGlu5 受体拮抗剂 (IC50:0.4 μM) 。
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SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) 是高选择性非竞争性 mGlu5 受体拮抗剂 (IC50:0.4 μM) 。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 343 | 现货 | |
2 mg | ¥ 496 | 现货 | |
5 mg | ¥ 818 | 现货 | |
10 mg | ¥ 1,280 | 现货 | |
25 mg | ¥ 2,590 | 现货 | |
50 mg | ¥ 3,970 | 现货 | |
100 mg | ¥ 5,750 | 现货 | |
500 mg | ¥ 11,500 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 766 | 现货 |
产品描述 | SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM) |
靶点活性 | mGlu5 (human):0.4 μM |
体内活性 | SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1]. |
别名 | 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 |
分子量 | 213.24 |
分子式 | C12H11N3O |
CAS No. | 31993-01-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 5.5 mg/mL (25.79 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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