ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM)

D4:12.4 nM(EC50), D4 receptor:12.4 nM(EC50)

ABT-724是一种选择性多巴胺D(4)受体激动剂，以12.4 nM的EC(50)和61%的效能激活人类多巴胺D(4)受体，而对多巴胺D(1)、D(2)、D(3)或D(5)受体无影响[1]。

ABT-724 在有意识的大鼠中，通过皮下注射（s.c.）的方式，呈剂量依赖性地促进阴茎勃起，此效果可被氟哌啶醇和氯氮平阻断，但多潘立酮则无此效应。通过脑室内而非脊髓内给药后观察到勃起功能增强效应，暗示作用位点在脑干上方。ABT-724 的皮下注射能增加自由活动且有意识的大鼠的海绵体内压。在西地那非存在下，ABT-724 对有意识大鼠的勃起功能增强效应得到增强。ABT-724 促进阴茎勃起的能力，加之其良好的副作用特性，表明ABT-724 对于治疗勃起功能障碍可能是有效的[1]。

ABT-724 (maleate salt) was freshly prepared and administered to rats via s.c. injection into the back neck area (1 ml/kg injection volume). For intracerebroventricular (ICV) or intrathecal administrations, rats were allowed at least 1 week of recovery from surgery before behavioral testing. The compounds of interest were infused ICV (left lateral ventricle) in a 5-μl volume or 10 μl intrathecally. After the experiment was completed, infusion of 0.5% fast-green dye in saline solution and subsequent dissection were carried out to confirm the diffusion of the injection solution[1].