MAO-IN-M30 dihydrochloride

产品编号 T38034Cas号 64821-19-8

别名 M 30 dihydrochloride

MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。

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MAO-IN-M30 dihydrochloride

产品编号 T38034别名 M 30 dihydrochlorideCas号 64821-19-8

规格	价格	库存
1 mg	¥ 237	现货
5 mg	¥ 496	现货
10 mg	¥ 738	现货
25 mg	¥ 1,180	现货
50 mg	¥ 1,890	现货
100 mg	¥ 2,680	现货
500 mg	询价	现货

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产品介绍

生物活性

产品描述	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
靶点活性	MAO-A:37 nM (IC50), MAO-B:57 nM (IC50)
体外活性	MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3]. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4].
体内活性	MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6].
别名	M 30 dihydrochloride