SR-1114

产品编号 T81108Cas号 2769141-82-2

SR-1114 是一种创新的PROTACENL降解剂，能够在MV4;11、MOLM-13和OCI/AML-2细胞中迅速降解ENL，其DC50值分别为150 nM 、311 nM 和1.65 μM。

产品编号 T81108Cas号 2769141-82-2

SR-1114 是一种创新的PROTACENL降解剂，能够在MV4;11、MOLM-13和OCI/AML-2细胞中迅速降解ENL，其DC50值分别为150 nM 、311 nM 和1.65 μM。

规格	价格	库存	数量
5 mg	询价	期货
50 mg	询价	期货

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生物活性

产品描述	SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
体外活性	Certainly, here is a revised version of the sentence: 'Ser nM TPP nM CUR (7)' is a chemical compound that exhibits specific activity, engaging in targeted interactions within a designated chemical or biological context. The notation encapsulates its unique structure and function. (Note: The sentence provided was incomplete and lacked context. I've crafted a general revision that addresses a typical description of chemical compound activity while retaining the original elements in parentheses and brackets. If there was additional information or specific jargon intended to be included, please provide the full sentence or context for more accurate assistance.)
体内活性	Ser nM TPP nM CUR (4 mg/kg; i.v. once) exhibits improved renal tissue distribution through KIM-1-receptor-mediated endocytosis within renal tubular epithelial cells, and it enhances the renal function in mice with acute kidney injury (AKI) [1].