CC-99677

产品编号 T39321Cas号 1887069-10-4

别名 CC99677, Gamcemetinib, CC 99677

CC-99677 (Gamcemetinib) 是一种一种用于自身免疫性疾病的选择性靶向共价MAPKAPK2(MK2)抑制剂，通过亲核芳族取代(SNAr)机制将生化效力转化为LPS活化的单核细胞THP-27细胞中热休克蛋白27(HSP1)磷酸化的有效抑制所显示的细胞效力。CC-99677 在大鼠实验中展现出在生化(IC 50 =156.3 nM)和细胞检测(EC 50 =89 nM)中均有

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CC-99677

产品编号 T39321别名 CC99677, Gamcemetinib, CC 99677Cas号 1887069-10-4

规格	价格	库存
1 mg	¥ 1,230	现货
5 mg	¥ 2,650	现货
10 mg	¥ 4,560	现货
25 mg	¥ 8,130	现货
50 mg	¥ 10,900	现货
100 mg	¥ 14,700	现货

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产品介绍

生物活性

产品描述	CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM).
体外活性	CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50 =156.3 nM) and cell based assays ( EC50 =89 nM).[1]
别名	CC99677, Gamcemetinib, CC 99677

化学信息

分子量	469.94
分子式	C₂₂H₂₀ClN₅O₃S
CAS No.	1887069-10-4

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 14.10 mg/mL (30 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1279 mL	10.6397 mL	21.2793 mL	106.3966 mL
5 mM	0.4256 mL	2.1279 mL	4.2559 mL	21.2793 mL
10 mM	0.2128 mL	1.0640 mL	2.1279 mL	10.6397 mL
20 mM	0.1064 mL	0.5320 mL	1.0640 mL	5.3198 mL