A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.

TRPA1 receptor (human):67 nM (IC50), TRPA1 receptor (rat):289 nM (IC50)

系统性注射A 967079（30 micromol/kg）降低了无损伤及CFA炎症大鼠在接受同侧后腿有害钳制刺激后的广动态范围（WDR）和伤害特异性（NS）神经元反应。同样，A-967079也减弱了OA及OA-sham大鼠在接受高强度机械刺激（300 g von Frey hair）对膝关节的WDR神经元反应。此外，A-967079还降低了CFA炎症大鼠在低强度机械刺激（10 g von Frey hair）下的WDR神经元反应，但在未受伤大鼠中无明显效果。A-967079注射后CFA炎症大鼠的WDR神经元自发活动也有所减少，但在未受伤、OA及OA-sham动物中未见变化[1]。

Separated by 5 min each, to specific stimulation of the neuronal RF were recorded. Spontaneous and evoked neuronal activity was then measured 5, 15, 25, and 35 min after systemic injection of A-967079 (30 μmol/kg) or vehicle (polyethylene glycol). The intravenous injection of A-967079 or vehicle was completed over a 6-7 min period. The i.v. dose of A-967079 was selected based on extrapolated plasma levels that were effective in behavioral studies . Except for 2 experiments in which two easily distinguished neurons were simultaneously recorded on one electrode, only one neuron was studied per rat. Since only one vehicle was used in these experiments, vehicle data was combined when a clear "no effect' was observed in at least 2-3 animals from a particular subset of groups (OA and sham OA)[1].