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信号通路 / 研究领域
为众多的药物研发团队赋能, 让新药发现更简单
肿瘤/癌症
肿瘤是一种由身体内的细胞失去正常生长控制而无限制地增生所致的一种严重疾病，可以发生在身体的任何部位，如肺、乳腺、结肠和皮肤等。癌症是全球健康的主要威胁之一，每年导致数百万人死亡，给患者及其家庭带来深重的痛苦和经济负担。近年来，癌症治疗领域取得了显著进展，尤其是在靶向疗法和免疫疗法等方面。研究者正在努力发现新的生物标志物和治疗方法，以进一步提高治疗效果。
免疫和炎症疾病
免疫和炎症疾病构成了一系列多样且复杂的健康问题，主要涉及免疫系统的异常反应。这类疾病包括类风湿性关节炎和系统性红斑狼疮等自身免疫疾病，以及哮喘和过敏性疾病等由于免疫系统对环境因素的过度反应所引起的病状。这些疾病的复杂性源于其发病机制，涉及遗传因素、环境影响以及生活方式等多重因素，它们不仅对个体健康构成挑战，也对公共卫生系统带来了重大负担。近年来，医学研究领域关注于解析和调节免疫系统的机制，以发展出更有效的治疗方法，包括精确调控免疫反应、开发针对特定免疫通路的创新药物，以及探索新的炎症反应缓解策略等。
神经退行性疾病
神经退行性疾病是一类影响神经系统的疾病，主要特征是神经细胞的逐渐退化和死亡。这类疾病包括阿尔茨海默病、帕金森病、亨廷顿病等，它们通常导致认知功能下降、运动能力受损以及其他神经功能障碍。随着全球人口老龄化，这些疾病的发病率正在逐渐上升，对患者及其家庭构成重大挑战。神经退行性疾病的确切原因仍然是科学研究的重点。目前认为，遗传因素、环境因素以及生活方式等都可能对这类疾病的发展有影响。由于这些疾病的症状和进展方式各不相同，因此对它们的研究和治疗也呈现出高度的复杂性。
内分泌和代谢疾病
内分泌和代谢疾病，如糖尿病、甲状腺功能紊乱、肾上腺疾病和肥胖症等，是由内分泌腺功能异常或代谢过程的紊乱引起的。内分泌系统，包括甲状腺、胰腺和肾上腺等，通过分泌激素来调控人体众多生理功能。这些激素直接影响身体的代谢过程，如物质的合成和分解。当这一平衡受到干扰时，可能导致能量代谢的异常，从而严重影响患者的日常生活和健康。近年来，研究的重点集中在开发针对这些疾病的新型治疗药物、优化现有的激素替代疗法，以及深入理解遗传和生活方式因素对这些疾病的影响。目标是提高治疗效果，减少药物副作用，并提升患者的生活质量。
心血管疾病
心血管疾病是指影响心脏和血管系统的一系列疾病，包括冠状动脉疾病（导致心绞痛和心肌梗死）、高血压、心力衰竭、脑血管疾病等。这些疾病通常与血管健康受损密切相关，例如动脉硬化，同时生活方式因素，如不健康饮食、缺乏运动、吸烟和过度饮酒等也是主要的因素。心血管疾病是全球主要的健康问题之一，是成年人死亡的主要原因之一。预防和治疗心血管疾病不仅需要关注生活方式的改变，药物治疗和手术干预也发挥着关键作用。研究者们致力于解析心血管疾病的发病机制，并开发和测试新的药物和治疗策略，以更有效地应对这类疾病的挑战。
传染病
传染病是由各种病原体（如细菌、病毒、真菌或寄生虫）引起的疾病，它们可能通过空气、食物、水或直接的人际接触等多种途径传播。常见的传染病包括流感、HIV/AIDS、结核病、疟疾和新型冠状病毒疾病等。这些疾病对全球公共卫生构成严重的威胁。在防治传染病的过程中，疫苗的开发、有效的抗生素和抗病毒药物的使用等扮演着重要的角色。为应对抗生素耐药性的不断增加和新兴传染病的挑战，新型小分子药物开发是战胜这些全球性健康威胁的重要策略。
类器官与干细胞
类器官（Organoids）是一种在实验室环境下培养的三维微型组织结构，能够模拟真实器官的细胞构成、结构和功能，已成为现代生物医学研究的重要工具。在构建疾病模型、药物筛选和毒性测试等方面发挥着关键作用。类器官通常来源于干细胞，在特定的培养条件下，干细胞能够分化成多种细胞类型，进而组合形成类器官。干细胞作为这一过程的核心，具有显著的自我更新能力和向各种细胞类型分化的潜能。
化合物库
我们可以提供800多种不同类型、结构、来源和规模的小分子化合物库，用于新药发现的高通量筛选，帮助药物开发人员发现有前景的化合物。
2024, 627(8002):149-156.Multisensory gamma stimulation promotes glymphatic clearance of amyloid
2023, 33(12):904-922.Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
2023, 33(12):940-951.Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
2023, 33(11):821-834.Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
2023, 33(1):46-54.Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1
2023, 41(7):1276-1293.e11.Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
2023, 186(13):2929-2949.e20.Distinct longevity mechanisms across and within species and their association with aging
2023, 624(7991):425-432.A novel antidiuretic hormone governs tumour-induced renal dysfunction
2023, 624(7992):663-671.Recognition of methamphetamine and other amines by trace amine receptor TAAR1
2023, 624(7992):672-681.Ligand recognition and G protein coupling of trace amine receptor TAAR1
2023, 621(7977):188-195.CRISPR screens decode cancer cell pathways that trigger γδ T cell detection
2023, 620(7974):676-681.GPCR activation and GRK2 assembly by a biased intracellular agonist
2022 Jan 17;61(3):e202113515.Multiplexed Small-Molecule-Ligand Binding Assays by Affinity Labeling and DNA Sequence AnalysisY
2022, 41(1):181-195.e9.Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma
2022, 32(7):687-690.The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
2022, 32(3): 288-301.Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate
文献引用
2024, 627(8002):149-156.
Multisensory gamma stimulation promotes glymphatic clearance of amyloid2023, 33(12):904-922.
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P2023, 33(12):940-951.
Cryo-EM structures of human organic anion transporting polypeptide OATP1B12023, 33(11):821-834.
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria2023, 33(1):46-54.
Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP12023, 41(7):1276-1293.e11.
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity2023, 186(13):2929-2949.e20.
Distinct longevity mechanisms across and within species and their association with aging2023, 624(7991):425-432.
A novel antidiuretic hormone governs tumour-induced renal dysfunction2023, 624(7992):663-671.
Recognition of methamphetamine and other amines by trace amine receptor TAAR12023, 624(7992):672-681.
Ligand recognition and G protein coupling of trace amine receptor TAAR12023, 621(7977):188-195.
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection2023, 620(7974):676-681.
GPCR activation and GRK2 assembly by a biased intracellular agonist2022 Jan 17;61(3):e202113515.
Multiplexed Small-Molecule-Ligand Binding Assays by Affinity Labeling and DNA Sequence AnalysisY2022, 41(1):181-195.e9.
Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma2022, 32(7):687-690.
The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis2022, 32(3): 288-301.
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate
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