AIM2

Interferon-inducible protein AIM2 is a protein that in humans is encoded by the AIM2 gene. AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin.AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA.