Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).
Mal-PEG4-VC-PAB-DMEA-Seco-DuocarmycinSA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic DuocarmycinSA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy.
DuocarmycinSA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.