antimicrobial compound 1

Antimicrobial Compound 1 是一种烷基吡啶鎓化合物，尾部为 12C，头部为 4-羧基。 Antimicrobial Compound 1 对枯草芽孢杆菌和大肠杆菌具有抗菌活性。

Asthma relating compound 1是一种潜在的抗哮喘化合物。

NPS ALX Compound 4a hydrochloride(1:1)是一种有效、选择性的 5-羟色胺受体 6 (5-HT6) 受体拮抗剂，IC50 值为 7.2 nM，且具有高亲和力，Ki 值为 0.2 nM。

Cancer-Targeting Compound 1可用于激素相关癌症的研究，包括治疗或预防肌瘤、子宫平滑肌瘤、多囊卵巢综合征或激素依赖性癌等等。

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) 是一种有效的选择性 VPS34抑制剂( IC50 : 15 nM)。

Compound SC-1是一种 Sorafenib 的衍生物，可抑制 STAT3磷酸化，通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡，具有抗癌作用。

Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。

Chlamydia pneumoniae-IN-1 是一种对衣原体有抑制作用的苯并咪唑类化合物，在低浓度下即可对肺炎衣原体产生抑制作用。Chlamydia pneumoniae-IN-1 具有抗菌活性，对CV-6菌株的 MIC 为12.6 μM，可用于研究肺部感染。

Neuromuscular-targeting compound 1 可用于研究肌肉萎缩和神经肌肉相关疾病。

Itch-Targeting Compound 1是一种止痒化合物，对昆虫叮咬的反应、对环境过敏原的反应、皮肤感染、外部恶臭或肾透析患者发生的瘙痒均可有效预防或治疗。

Antiasthmatic Compound 1 is an antiasthmatic agent.

Antibacterial compound 1 is an antibacterial compound.

Antimicrobial Agent-1 (compound 6C) shows strong activity (MIC = 2 μg/mL) against TolC mutant E. coli. Additionally, it synergistically interacts with Colistin to exhibit enhanced activity against Gram-negative bacteria. Importantly, Antimicrobial Agent-1 exhibits no cytotoxic effects on mammalian cell lines. Its MIC values on Caco-2 and Vero cell lines are greater than 128 μg/mL [1].

(Rac)-Neurodegenerative Disorder-Targeting Compound 1为一种针对神经退行性疾病的化合物，具有calpain抑制活性。

Antimicrobial photosensitizer-1 为抗病原微生物感染的潜在光敏剂，其在金黄色葡萄球菌感染小鼠伤口模型中显示出显著的抗菌活性。

Urinary Incontinence-Targeting Compound 1, used in the research of urinary incontinence, is a sulfonanilide derivative.

Arrhythmias-Targeting Compound 1 is a compound. It is used in the research of arrhythmias.

Neurodegenerative Disorder-Targeting Compound 1 是一种靶向 calpain 的抑制剂。

Arrhythmic-Targeting Compound 1 is used for arrhythmic disease, with nitrogen-containing spirocycles.

Neuromuscular Disorder-Targeting Compound 1 is utilized in research for neuromuscular disorders, including chronic fatigue syndrome and fibromyalgia syndrome symptoms.

Antimicrobial agent-29 (Compound C35) 对人血红蛋白与金黄色葡萄球菌IsdB hemophore 蛋白的相互作用产生影响，促进了IsdB:Hb PPI抑制剂的开发。

Cyclopeptide 1 (Compound 1) 是抗菌肽，对 B. subtilis 表现出中等抑制效果，最小抑菌浓度 (MIC) 为 25 μg/mL。

Desacetylcefotaxime, Cefotaxime的一种体内代谢物，具有类似其母体化合物对多种需氧和厌氧细菌的体外抗菌活性。

Pulcherriminic acid 是环状二肽抗菌剂，对Fe3+有高亲和力，主要在芽孢杆菌和酵母中发现。该化合物通过非酶促反应与铁离子螯合，生成细胞外红色素pulcherrimin，通过竞争铁营养达到抗菌效果。Pulcherriminic acid 在食品、农业和医疗等领域具有广泛应用潜力。

FabH-IN-1 (化合物 3f) 可有效对抗革兰氏阳性菌和革兰氏阴性菌，并且也是一种良好的抗氧化剂。FabH-IN-1 是细菌FabH 酶的抑制剂，该酶是一种广谱抗菌靶标。

NusB-IN-1 (Compound 22r) is a highly effective bacterial rRNA synthesis inhibitor, administered orally. It exhibits potent antimicrobial activity against MRSA and VRSA [1].

Complestatin is a compound extracted from Streptomyces lavendulae mycelia; on acid hydrolysis yields D-4-hydroxyphenylglycine & D-3,5-dichloro-4-hydroxyphenylglycine & acidic chromophore; inhibits gp120-CD4 binding. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity. It has a role as a metabolite, an antimicrobial agent and an anti-HIV-1 agent.

Piperacillin-d5 是 Piperacillin 的氘代化合物。Piperacillin 的 CAS 号为 61477-96-1。Piperacillin 是半合成青霉素，可以作用于革兰氏阳性和革兰氏阴性需氧和厌氧菌。与其他青霉素相比，它对产生 β-内酰胺酶的菌类表现出更强的活性。

Maximin 78为一种具有广谱抗菌性能的肽类化合物。该化合物展现出针对C. albicans、S. aureus、B. subtilis的显著抗菌活性，最小抑菌浓度（MIC）分别为37.5、4.7、37.5 μg/mL。此外，Maximin 78对人类和兔子红细胞显示出溶血活性。

Des(8-14)brevinin-1PMa是一种具有抗金黄色葡萄球菌和大肠杆菌活性的宿主防御肽，同时也表现出溶血性。

Cyclo(Gly-His)为脂质体封装的环状二肽，显示出抗菌及抗癌特性。该化合物对HeLa细胞和MCF-7细胞表现出显著的细胞毒作用，IC50值分别为1.699 mM和0.358 mM。Cyclo(Gly-His)主要用于药物递送系统的研究领域。

Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).

Bombinin H4，蛾Bombina variegata皮肤中的抗菌肽，其对大肠杆菌D21和金黄色葡萄球菌Cowan 1的致死浓度分别为4.8 μM和3.3 μM。

C16-K-cBB1 是一种对 MRSA(甲氧西林耐药金黄色葡萄球菌)有效且选择性的抗菌剂，其 MIC 为 1 μg/mL。C16-K-cBB1 具有很好的选择性，由于其溶血活性较弱。在 12.5 μg/mL 浓度下，C16-K-cBB1 能够在 120 分钟内杀死 MRSA 细胞。

Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg L, respectively).[1] It reduces cadmium-induced increases in hepatic levels of thiobarbituric acid reactive substances (TBARS) and increases cadmium-induced decreases in the hepatic activity of superoxide dismutase (SOD1), catalase, GST, and glucose-6-phosphate dehydrogenase (G6PDH) in rats when administered at a dose of 40 mg kg.[2] Diallyl tetrasulfide is cytotoxic to MCF-7 breast cancer cells (IC50 = 92 μM) and reduces tumor growth in a BGC-823 mouse xenograft model when administered at doses of 20, 30, and 40 mg kg for 32 days.[3],[4]

Metallo-β-lactamase-IN-5 (compound 5c) is a powerful inhibitor of metallo-β-lactamases (MBLs). Its inhibitory activity against MBLs NDM-1 and VIM-1 has been demonstrated. With an IC50 value of 45 μg mL, Metallo-β-lactamase-IN-5 effectively inhibits HUVECs. Additionally, when combined with Imipenem, Metallo-β-lactamase-IN-5 exhibits synergistic antimicrobial activity [1].

NDM-1 inhibitor-4（compound 27）作为一种有效的NDM-1抑制剂，展现出Ki值为1.7 μM的抑制活性，并具备抗菌能力。

Garvicin KS（GarKS）、GakC 是由32个氨基酸构成的肽，与GakA和GakB共同组成细菌素Garvicin KS。它能抑制成纤维细胞的活性和增殖。此外，Garvicin KS肽对MSSA具有抑制作用，MIC值依次为GakB > GakC > GakA。

Clindamycin phosphate (Clindamycin 2-phosphate) hydrochloride 是一种广谱抑菌林可酰胺类抗生素 (antibiotic)。Clindamycin phosphate hydrochloride 是Clindamycin 的前体活性分子，在体外不具有抗菌活性 ，但在体内可通过磷酸酶酯水解迅速转化为具有活性的母体活性分子 Clindamycin。Clindamycin phosphate hydrochloride 可用于痤疮和细菌性阴道病的研究。

Antimicrobial agent-7 (Compound 12) 为一化合物，对革兰氏阴性及革兰氏阳性菌展现出显著的抗菌能力，MIC值介于 2-8 μg/mL 之间。此外，该化合物还对脂多糖引发的炎症有着抗炎作用。

Antimicrobial agent-12 是一种有效的抗菌剂，同时具有 SARS-CoV-2 抑制活性。

Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。

Brevianamide M (compound 4)为Aspergillus versicolor代谢物，该物质源自海洋褐藻Ecklonia马尾藻中分离的内生真菌。Brevianamide M展示出针对大肠杆菌和金黄色葡萄球菌的抗菌活性。

Oleanolic aldehyde 是一种具有抗菌性质的化合物，能够抑制口腔内细菌生长。该化合物对变形链球菌和牙龈卟啉单胞菌——与龋齿和牙周病有关的细菌——显示出显著的抑制效果，其最低抑菌浓度(MICs)分别为488 μg/mL和250 μg/mL。

GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase, with an IC50 of 3.47 μM. This compound demonstrates remarkable antimicrobial activity and exhibits excellent penetration in the central nervous system. Additionally, GlcN-6-P Synthase-IN-1 is capable of inhibiting cytochrome P450, specifically the CYP3A4 isoform [1].

MraY-IN-1 (compound 12a) 是细菌转位酶 MraY 的有效抑制剂 (IC50: 140 μM)。MraY-IN-1 对大肠杆菌 K12 (MIC50: 7 μg/ml)、枯草芽孢杆菌 W23 (MIC50: 12 μg/ml) 和荧光假单胞杆菌 Pf-5 (MIC50: 46 μg/ml) 具有抗菌作用。MraY-IN-1 能够用于抗菌的研究。

Variculanol，从海洋真菌Aspergillus versicolor中提取，具有抗菌、抗癌和抗HCV NS3/4A 蛋白酶活性。

Daldinone A (Compound 4) ，一种从稻黑孢菌 (Nigrospora oryzae) 分离得到的化合物，显示了对铜绿假单胞菌 (P. aeruginosa) 的抗菌活性。