arteries

YT 146 是一种选择性腺苷受体 A2 激动剂，具有心脏保护和血管舒张作用，可抑制大鼠股动脉内皮损伤后的新内膜增厚。

Elsibucol (AGI 1096) 是一种VCAM1抑制剂，可用于研究器官移植排斥。Elsibucol 是一种代谢稳定的丙醇衍生物，具有抗氧化、抗炎和抗增殖的特性。它能降低血液中的胆固醇水平，减少受伤动脉中的氧化应激和炎症反应，从而抑制动脉粥样硬化，保护动脉损伤后的内皮愈合。

Xanthinol Nicotinate (Complamin) 是血管扩张剂，可直接作用于小动脉和毛细血管的平滑肌，能够扩大血管，改善血液流变学并降低外周血管阻力。

Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。

Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。

Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂，可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞，导致主要冠状动脉和全身动脉扩张，降低心肌收缩力。它常用于心肌功能不全的相关研究。

Zolmitriptan (311C90) 是一种5-HT1B 1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。

Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂，具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂，也是一种潜在可行的帕金森病神经保护剂。

Ticlopidine hydrochloride (Ticlodix) 是一种 ADP 受体抑制剂，对血小板凝集的IC50为2 μM。

Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) 是从丹参中提取的丹参酮IIA 的水溶性衍生物，是SOCE 抑制剂，用于心血管疾病的研究。

Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。

Darusentan (Lu-135252) 是内皮素受体 A (ET-A) 受体选择性拮抗剂，能够作用于 ET-A 受体(Ki:1.4 nM)及ET-B 受体(Ki:184 nM)，对 ETA 受体的选择性大于 ETB 受体的100以上。它在大鼠主动脉血管平滑肌细胞膜中竞争结合放射性标记的内皮素(Ki:13 nM)。

RHC 80267 (U-57908) 是一种选择性二酰基甘油脂酶(DAGL)抑制剂，对犬血小板的IC50为 4 μM。它抑制COX 活性和磷脂酰胆碱的水解，还抑制胆碱酯酶活性，IC50为 4 μM，增强乙酰胆碱引起的松弛。

SAR407899 是一种选择性的 ATP 竞争性ROCK 抑制剂，对ROCK-2的IC50值为 135 nM，对人和大鼠ROCK-2的Ki 值分别为 36 和 41 nM。它是 Rho 激酶抑制剂，有效抑制 endothelin-1 诱导的肾阻力动脉收缩。

MBCQ 是选择性 cGMP 特异性磷酸二酯酶 (PDE V; PDE5) 抑制剂，IC50=19 nM。它通过特异性抑制 cGMP-PDE 来扩张冠状动脉。它对其他 PDE 同工酶没有抑制活性，IC50均大于 100 µM。

Dapiprazole Hydrochloride (Glamidolo Hydrochloride) 是 α-adrenergic 阻断剂的药物。

MONNA 是 TMEM16A (Anoctamin-1)阻滞剂，IC50为 80 nM。它在氯离子存在或不存在的情况下诱导啮齿动物抵抗动脉的血管舒张。

Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化，显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。

PRX-08066是5-HT 受体2B 拮抗剂，IC50为3.4 nM，可诱​​导肺动脉的选择性血管舒张。

AM404 is a chemical compound that functions as an inhibitor of endocannabinoid reuptake. It effectively blocks the transport of anandamide, with IC50 values measured in the low micromolar range. Moreover, AM404 exhibits the ability to induce relaxation in rat isolated hepatic arteries contracted with Phenylephrine. This relaxation effect is quantified by a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Additionally, AM404 possesses a neuroprotective effect.

SKA-111 是一种选择性钙离子激活的钾离子通道 (potassium phannel ) KCa3.1 激活剂，可引起猪内皮细胞膜超极化。SKA-111结合在CaM N-瓣和S4-S5接头之间的界面中，能够改善 Bradykinin 诱导的离体大鼠心脏的冠状动脉扩张，可用于研究心血管疾病。

Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) 是 Ferulic acid 的代谢物。Ferulic acid 4-O-sulfate 可以放松小鼠的动脉，降低血压，在小鼠和 HepG2 细胞的铁过载条件下对氧化应激的抵抗作用。

TAS-301 是一种平滑肌迁移和增殖抑制剂，能够抑制 PDGF 诱导的 PKC 的活化，可抑制大鼠颈动脉球囊损伤后的内膜增厚。

Histamine Phosphate (Histamine acid phosphate) 是组胺受体的强激活剂和血管扩张神经剂，可激活一氧化氮合成酶。

Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。

Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽，是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程，增加无溶质水从肾小管的滤液中重新吸收回循环中的量，收缩小动脉提高压强，增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质，与特定的 G 蛋白偶联受体结合发挥作用。

CGP48369 是一种有效的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，具有降血压作用，可增强自发性高血压大鼠冠状动脉的内皮依赖性松弛。

14R(15S)-EET 是一种氧脂素和花生四烯酸的代谢产物。它通过细胞色素P450 (CYP) 亚型CYP2C8和CYP2C9对花生四烯酸的氧化作用生成。14R(15S)-EET (10 µM) 可诱导预收缩的离体牛冠状动脉放松。

Angiopeptin is a synthetic octapeptide analog of somatostatin; suppresses accelerated transplant atherosclerosis in rabbit heart arteries.

(±)16,17-EDT，一种经由细胞色素P450 (CYP) 途径形成的腺苷酸代谢物和氧脂肪酸，能够诱导分离的猪小动脉舒张（EC50 = 11 pM）。此外，(±)16,17-EDT 亦能促进以TP受体激动剂U-46619 预收缩的分离牛冠状动脉的松弛。

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone.

(±)13,14-EDT是一种氧脂和腎上腺酸的代谢产物，通过细胞色素P450（CYP）途径形成。在50 nM的浓度下，它能激活分离的大鼠冠状小动脉平滑肌细胞中的大导电钙激活钾通道（KCa1.1/BK），并导致分离的猪小动脉扩张（EC50 = 12 pM）。(±)13,14-EDT还能使用TP受体激动剂U-46619预收缩的分离牛冠状动脉放松。

RA-2 is a pan-negative-gating modulator of KCa2 3 channels that acts by inhibiting EDH-type relaxation in coronary arteries.

1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, causing vasodilation in the coronary artery pre-contracted with 1 μM 5-hydroxytryptamine (5-HT), with an EC 50 value of 6.6±1.4 μM.

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.

(±)17(18)-EpETE-Ethanolamide, an ω-3 endocannabinoid epoxide, originates from eicosapentaenoic ethanolamide (EPEA) through cytochrome P450 (CYP) epoxygenases action and is decomposed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FA, AH). Its endogenous synthesis occurs in LPS-stimulated and EPEA-supplemented BV-2 microglia cells, a process inhibited by the CYP inhibitor ketoconazole. This compound mitigates IL-6 and nitrite levels while enhancing IL-10 production following LPS exposure in BV-2 microglia. At a dose of 50 µM, it prevents platelet aggregation caused by arachidonic acid but not that triggered by ADP, collagen, or ristocetin. Additionally, it facilitates the dilation of constricted bovine coronary arteries (ED50= 1.1 µM) and blocks VEGF-driven tubulogenesis in human microvascular endothelial cells (HMVECs).

3',4'-Dihydroxyflavonol (DiOHF) is an efficient antioxidant that diminishes superoxide levels and enhances nitric oxide (NO) functionality in the mesenteric arteries of diabetic rats[1].

Prostaglandin D1 是对离体人动脉具有收缩和舒张作用的一种前列腺素，能抑制 ADP 诱导的血小板聚集（ IC50=320 ng ml）。Prostaglandin D1 可用于代谢研究。

Tilisolol is a nonselective blocker of beta-adrenergic. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs.

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.

(±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries. The synthesis of this analog involves the formation of the epoxide at the 14,15-double bond, however, epoxidation can also occur at the 8,9-double bond. (±)8(9)-EE-14(Z)-E is a minor product from the synthesis of (±)14(15)-EE-8(Z)-E. This compound has not been reported in the literature, and its biological activity is not known. It may serve as a tool to verify that the parent compound, (±)14(15)-EE-8(Z)-E, is pure and does not contain the 8,9-epoxy regioisomer.

(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.

Adrenomedullin(porcine)是一種多肽，具有调节血管舒张的功能。它在内皮依赖性条件下能诱导大鼠主动脉舒张，IC50为2.4 nM；在内皮非依赖性条件下则能诱导猪冠状动脉舒张，IC50为27.6 nM。

Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) 是UTP的一种抗水解衍生物，是嘌呤P2Y2受体的激动剂。在表达人类P2Y2受体的1321N1星形胶质瘤细胞中，其可诱导肌醇磷酸盐的形成（EC50 = 240 nM），并且在来自囊性纤维化患者的原代鼻上皮细胞中以浓度依赖的方式诱导氯离子分泌。UTP-γ-S在分离的人类冠状动脉中诱导血管收缩（EC50 = 25.1 µM）。

N-Arachidonoyl-L-serine (ARA-S), a recently isolated endocannabinoid with a distinct activity profile that diverges from typical endocannabinoids, does not interact with central cannabinoid (CB1), peripheral cannabinoid (CB2) receptors, or vanilloid receptor 1 (VR1). Unlike other compounds, ARA-S (5 mg kg) counteracts the lowering of blood pressure induced by a 10 mg kg intravenous bolus of abnormal cannabidiol (Abn-CBD) in anesthetized rat models. Additionally, akin to Abn-CBD, ARA-S induces relaxation in isolated rat mesenteric arteries and abdominal aorta and promotes phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in human umbilical vein endothelial cells (HUVEC). The mechanisms through which ARA-S and Abn-CBD exert their effects on vascular systems show variations and merit deeper investigation.

[Tyr(P)4] Angiotensin II is a peptide that exerts a multitude of effects on vascular smooth muscle. These effects include the contraction of normal arteries, as well as the induction of hypertrophy or hyperplasia in cultured cells or diseased vessels.

Rizatriptan benzoate (MK-462 Benzoate) 是 5-HT1激动剂，通过选择性结合并激活血清素 (5-HT) 1B 受体和 5-HT 1D 受体，从而缓解偏头痛。

Rizatriptan sulfate is a selective serotonin 5-HTID receptor agonist derived from tryptamine.

Rizatriptan is an agonist of the serotonin-1b and serotonin-1d receptor.