bms-512148 1,2-propanediol, hydrate

Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体，是竞争性葡萄糖协同转运蛋白2 抑制剂，可促进尿液中葡萄糖的排泄，可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。

1-Phenyl-1,2-ethanediol 是 O-benzyl oxime ether 衍生物，用作杀虫剂。

1-Phenylpropane-1,2-dione (Acetyl benzoyl) 是麻黄素生物碱的生物合成前体，分离自从嫩麻黄中。

D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体，包括糖酵解和糖异生。在糖酵解过程中，它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中，D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源，这一途径已成为癌症化疗的主要靶点。

(±)-1,2-Propanediol 是一种脂肪族醇，具有多种作用，可作为防腐剂和防冻剂，在食品工业和护肤品行业应用广泛。 (±)-1,2-Propanediol 是一种天然抑菌剂，能够在一定程度上抑制细菌的生长和繁殖

BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) 是 HER1 和 HER2 的选择性抑制剂（IC50：20 nM 和 30 nM），对 HER4 的效力降低约 8 倍，对 Lck、VEGFR2、c-Kit、MET 等的效力降低 100 倍以上。

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv在Sprague Dawley大鼠上进行测试时显示出高局部抗炎效力和高肺选择性。

BMS-1 (PD-1 PD-L1 inhibitor 1)是一种 PD-1 PD-L1蛋白质 蛋白质相互作用的抑制剂，IC50为 6 到 100 nM。

(2S,4R)-1-((9H-Fluoren-9-yl)methyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66076，CAS号为 122350-59-8。

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1 1.Hyman, J.M., Firestone, A.J., Heine, V.M., et al.Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockadeProceedings of the National Academy of Sciences of the United States of America106(33)14132-14137(2009)

4,4'-(Cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-2-carbaldehydE) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64484。

α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-D-tyvelose biosynthesis inS. typhi.3Bacterial sucrose phosphorylase converts sucrose and phosphate into D-fructose and α-D-glucose-1-phosphate.4 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen breakdown requires the interplay of several enzymesBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen is synthesized and degraded by different pathwaysBiochemistry(2002) 3.Koropatkin, N.M., and Holden, H.M.Molecular structure of ɑ-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhiJ. Biol. Chem.279(42)44023-44029(2004) 4.Goedl, C., Schwarz, A., Minani, A., et al.Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: Characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of ɑ-Ｄ-glucose 1-phosphateJ. Biotechnol.129(1)77-86(2007)

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol 是当归地上部分的主要活性成分，能显著抑制嗜水气单胞菌的生长，并具有抗凝及抗生素活性。

(R)-2-Amino-3-cyclohexylpropanoic acid hydrate(1:x) 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66758，CAS号为 213178-94-0。

5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase. N/A

4-(1-Ethoxy-2-hydroxyethyl)benzene-1,2-diol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126255。

1-O-(4,4'-Dimethoxytrityl)-3-O-succinyl-l,3-propanediol is a Fine Chemical.

threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5142，CAS号为 848031-94-7。

4-C-(Iodomethyl)-1,2-di-O-(1-methylethylidene)-3,5-bis-O-(phenylmethyl)-a-D-ribofuranose is a Carbohydrate Derivative.

Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) 是一种可逆的竞争性胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 抑制剂，对 Tryptase、Trypsin、uPA、Factor Xa、Thrombin 和 tPA 的Ki 值分别为 20、21、97、110、320 和 750 μM。

β-Glycerophosphate Disodium Salt Hydrate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition and functions as an organic phosphate donor.

4-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64514，CAS号为 174671-88-6。

1-Isomangostin hydrate 是一种从山竹藤中提取的天然产物。它具有抗真菌活性。

(R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, which is derived from glucose through the expression of NADH-linked glycerol dehydrogenase genes in Escherichia coli.

1-tert-Butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66754，CAS号为 251924-83-1。

(S)-1-Benzyl 2-methyl pyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65353，CAS号为 5211-23-4。

DPP1-IN-1 hydrate作为一种有效的DPP1抑制剂（IC50: 1.6 nM），展现出了优良的生物利用度与药代动力学属性，适用于炎症性疾病的科学研究。

N-(1-((6aR,8R,9aR)-9-Cyano-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67388。

(S)-1-Benzyl 2-tert-butyl pyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65611，CAS号为 16881-39-3。

3-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2885，CAS号为 22805-15-8。

erythro-1-Phenylpropane-1,2-diol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4002，CAS号为 40421-52-1。

β-Aflatrem是一种天然产物，属于金粟兰科金粟兰属，其产品编号为 TN2486，CAS号为 20133-19-1。β-Aflatrem可用作对照参考。

3-Chloro-1,2-Propanediol-d5 是 3-Chloro-1,2-Propanediol 的氘代化合物。3-Chloro-1,2-Propanediol 的 CAS 号为 96-24-2。

4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3001，CAS号为 577976-26-2。

BMS-433771 dihydrochloride hydrate 是一种有效的呼吸道合胞病毒 (RSV) 抑制剂，具有口服活性。BMS-433771 dihydrochloride hydrate 对 A 组和 B 组RSV 均有效，EC50均值为 20 nM。BMS-433771 dihydrochloride hydrate 可用于呼吸道疾病的研究。

(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66075，CAS号为 16217-15-5。

Phenol, m-(1-(p-hydroxyphenethyl)-3-isopropyl-3-pyrrolidinyl)-, hydrochloride, hydrate is a bioactive chemical.

1,2-Epoxy-1-hydroxymethylpyrrolizidine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125765。

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin/CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin/CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg/kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg/kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg/kg/day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

α-D-Glucose-1-phosphate disodium hydrate 为合成葡萄糖醛酸的初始原料之一，同时，在心脏病研究领域，亦被广泛应用作为细胞抑制剂、抗生素、免疫抑制剂与循环系统研究的关键材料。

1-Benzyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65605，CAS号为 155075-23-3。

(S)-(+)-1,2-Propanediol is an endogenous metabolite.

erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4001，CAS号为 1280602-81-4。