clobenpropit

Clobenpropit dihydrobromide 是一种组胺H3R 拮抗剂 反向激动剂。它与 5-HT3 受体和 α2A α2C 肾上腺素受体结合，对组胺H4受体起部分激动剂的作用，还能促进凋亡。

Clobenpropit 2HBr is a histamine H3 receptor antagonist. It has neuroprotective effects via stimulation of GABA release in the brain.

A-943931 is a histamine H4receptor antagonist (Ki= 3.8 nM).1In vivo, A-943931 inhibits scratching induced by clobenpropit in mice (ED50= 26 μmoles/kg, i.p.). 1.Milicic, I., Witte, D.G., Miller, T.L., et al.Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activityFASEB J.23(S1)760.768-760.768(2009)