CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linkerconjugates[1].
NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drugconjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrates potent efficacy against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50 values of <7 pM and 40 pM, respectively.
MC-Val-Cit-PAB-Indibulin is an antitumor drug-linker conjugate for antibody-drugconjugates (ADCs), featuring the orally active tubulin assembly inhibitor, Indibulin, connected through the MC-Val-Cit-PAB ADClinker. This compound exhibits potent antitumor activity.
MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drugconjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADClinker MC-Val-Cit-PAB.
MC-VC-PABC-DNA31 is a drug-linker conjugate designed for Antibody-DrugConjugates (ADC) that demonstrates potent antitumor activity. It employs DNA31, an effective inhibitor of RNA polymerase, connected through the MC-VC-PABC ADClinker.
Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for antibody-drugconjugates (ADCs) that combines the ADClinker (Acetylene-linker-Val-Cit-PABC) with the potent tubulin inhibitor MMAE.
Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-DrugConjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic agent, connected through the ADClinker[1].
N3-PEG3-vc-PAB-MMAE, a drug-linker conjugate designed for Antibody-DrugConjugates (ADC), features the integration of monomethyl auristatin E (MMAE), a tubulin inhibitor, via a 3-unit polyethylene glycol (PEG) linker. This compound demonstrates significant antitumor activity.
SPP-DM1, a drug-linker conjugate for antibody-drugconjugates (ADC), demonstrates potent antitumor activity. It comprises DM1 (a potent microtubule-disrupting agent) connected through the ADClinker SPP[1].
PEG4-aminooxy-MMAF is a drug-linker conjugate designed for antibody-drugconjugates (ADC) that exhibits potent antitumor activity. It incorporates MMAF, a powerful antitubulin agent, connected through a non-cleavable PEG4 linker[1].
MMAE-SMCC is a drug-linker conjugate designed for antibody-drugconjugates (ADC). It consists of MMAE, a potent inhibitor of mitosis and tubulin, and SMCC, a linker that facilitates the development of ADCs.
MC-Sq-Cit-PAB-Gefitinib is a potent antitumor drug-linker conjugate for Antibody-DrugConjugates (ADC), utilizing Gefitinib—an EGFR tyrosine kinase inhibitor—connected through the MC-Sq-Cit-PAB ADClinker.
Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drugconjugates (ADC), combines the cleavable ADClinker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682.
Mal-VC-PAB-DM1, a drug-linker conjugate for antibody-drugconjugates (ADCs), exhibits potent antitumor activity. It incorporates DM1, a potent microtubule-disrupting agent, connected through the ADClinker Mal-VC-PAB [1].
MP-PEG8-VA-PABC-PBD Dimer is a drug-linkerconjugatesforADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].
Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a novel approach to cancer treatment. Eribulin is specifically utilized in creating targeted Eribulin-based drugs for antibody conjugates[1].
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drugconjugates (ADC), comprises the ADClinker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of nemorubicin (MMDX) from liver microsomes and the ADC cytotoxin PNU-159682[1].
MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-DrugConjugates (ADC), utilizing Dolastatin10 (a tubulin polymerization inhibitor) connected through the MC-Sq-Cit-PAB ADClinker.
MC-Val-Cit-PAB-rifabutin is a drug-linker conjugate designed for antibody-drugconjugates (ADC), featuring the potent antitumor agent rifabutin (a DNA-dependent RNA polymerase inhibitor) connected through the MC-Val-Cit-PAB ADClinker. This configuration endows it with significant antitumor activity.
MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-DrugConjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADClinker.
DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drugconjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1].
MC-Val-Cit-PAB-Retapamulin is a drug-linker conjugate for antibody-drugconjugates (ADC) that exhibits potent antitumor activity. This compound utilizes Retapamulin, a ribosome inhibitor, connected through the ADClinker MC-Val-Cit-PAB.
MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 druglinker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells
AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugate for antibody-drugconjugates (ADCs), featuring a natural bis-intercalator, SW-163D, attached through an AcLysValCitPABC-DMAE linker[1].
7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-based linkerfor PROTACs which joins two essential ligands, crucial forforming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.
MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB.
DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drugconjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].
DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linkerfor the development of antibody-drugconjugates (ADCs). This conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1’s capabilities as an antibody-conjugatable maytansinoid.