hg 9 91 01

HG-9-91-01 (SIK inhibitor 1) 是选择性的盐诱导型激酶 (SIK) 抑制剂，能够作用于 SIK1(IC50:0.92 nM)、SIK2(IC50:6.6 nM)和 SIK3(IC50:9.6 nM)。

HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S 抑制剂，IC50分别为20.3 nM 和3.2 nM。

HG-7-86-01（Compound 26）为一种II型酪氨酸激酶抑制剂，具备显著的抗增殖活性。

Flagelin 22 TFA (Flagellin 22 TFA), a fragment of bacterial flagellin, is an effective elicitor in both plants and algae.

Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the formation of SNIPER [1].

HG-7-85-01-NH2 是 SNIPER(ABL)-033 的配体。该化合物通过将 HG-7-85-01 (ABL 抑制剂) 透过 linker 与 LCL161 衍生物 (IAP 配体) 结合形成 SNIPER(ABL)-033，该结合物能有效促进 BCR-ABL 蛋白的降解，表现出 0.3 μM 的 DC50 值。

HG-7-85-01 is a type II ATP competitive inhibitor targeting wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. It effectively inhibits T315I mutant Bcr-Abl kinase, as well as KDR and RET kinases with IC50 values of 3 nM, 20 nM, and 30 nM, respectively. In contrast, HG-7-85-01 exhibits weak or no inhibition towards other kinases (IC50 >2 μM). Furthermore, this compound inhibits cell proliferation through the induction of apoptosis and by impeding cell-cycle progression.

Flagelin 22 acetate 是细菌鞭毛蛋白的一部分，是在植物和藻类中一种有效的诱导剂。

Flagelin 22, a bacterial flagellin fragment, serves as a potent elicitor for plants and algae.