hormonal

Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物，与靶器官中的孕酮受体和雌激素受体高亲和力地结合，可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素，用作激素避孕药。

Ospemifene (FC-1271a) 是非雌激素的选择性雌激素受体调节剂，能够作用于雌激素受体α (Kis:380 nM)和 Erβ (Kis:410 nM)。它可用于研究阴道萎缩乳腺癌。

4-Nonylphenol polyethoxylate (Nonoxinol-9) 是一种表面活性剂，普遍用作避孕药中的杀精剂。

Testosterone undecanoate 是一种睾酮酯，是睾酮的代谢产物，睾酮是很有前途的男性激素避孕雄激素。

Nilutamide (RU23908) 是一种非甾体抗雄激素药物，有用于转移性前列腺癌的潜力。

Lotrifen (Privaprol) 是一种非激素抗生育药物，Lotrifen 引起妊娠停止和复旧。在胚泡着床后，它直接作用于受精卵，受精卵经历一个缓慢而逐渐的退化过程，并以受精卵的再吸收或排出而结束。

CDD-1102 HCl 是一种新型BRDT-BD4 BRD2-BD1302选择性抑制剂，在体内外实验中显示出非激素避孕潜力。

Gastrin I (1-14), human 是人胃泌素 I 肽的 1-14 片段。其中Gastrin I 是内源性胃肠肽激素。Gastrin 是胃酸分泌的主要激素调节剂。

Cabergoline (FCE-21336) 是一种麦角衍生的多巴胺 D2亚类受体激动剂，高亲和力作用于D2、D3和5-HT2B 受体，Ki 分别为 0.7、1.5 和 1.2。

Gestodene (WL 70) 是一种孕激素类避孕药。

Liarozole (R75251 dihydrochloride) 是一种咪唑衍生物，是一种具有口服活性的维甲酸 (RA) 代谢阻断剂(RAMBA)，具有抗肿瘤作用。它能够抑制维甲酸依赖的细胞色素P450(CYP26) 4- 羟基化 (IC50=7 μM)，导致组织维甲酸水平增加。

Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。

Vamorolone (VBP15) 是一种首创的，具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。它抑制 (NF-κB) 抑制作用，并降低了激素的影响。它改善肌营养不良，无副作用。

Goserelin acetate (Fertilan) 是一种促性腺激素释放激素 (GnRH LHRH) 十肽类似物，能作为GnRH 激动剂。它可研究乳腺癌、上皮性卵巢癌和前列腺癌。

Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.

3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output. It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-induced hibernation for medical purposes.

Cabergoline diphosphate is a dopamine D2 receptor agonist used for prolactinoma treatment. Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.

Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式，可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性，抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。

CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.

Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。

Nomegestrol is a progestin. It is used in the treatment of gynecological disorders, in menopausal hormone therapy for the treatment of menopausal symptoms, and in hormonal contraceptives.

Thymus peptide C, a hormonal drug derived from the thymus glands of young calves, acts as a substitute for the physiological functions of the thymus.

Tesmilifene 是一种抗组胺剂和化学增敏剂。其作用靶向细胞色素 P450 (cytochrome P450)，在 MCF-7 细胞中对 DNA 合成产生激素效应，并刺激小鼠 大鼠模型中的肿瘤生长。此外，Tesmilifene 能够克服多药耐药性。

Chronic intracerebroventricular (ICV) injection of a VGF peptide named TLQP-21 increased resting energy expenditure and temperature in mice. Furthermore, in mice fed a high-fat diet, the same peptide prevented the increase in body and white adipose tissue

8′-Hydroxy ABA (8'-OH-ABA) 为脱落酸 (ABA) 的主要分解产物，该化合物具备激素活性，能促进油合成。然而，8′-Hydroxy ABA 是一种不稳定的化合物。

Neuronostatin-13 human acetate(1096485-24-3 free base) 是一种 13 个氨基酸的肽类激素，在调节激素和心脏功能中起重要作用。

GW5638 is a estrogen receptor ligand. GW5638 is a prodrug of its active metabolite GW7604. GW5638 appears to act as an antagonist in these in vitro systems, although in a manner distinct from other known ER modulators. GW5638 is also classified as a pseud

7'-Hydroxy ABA (7'-OH ABA) 是由 Abscisic acid (Abscisic acid) 通过羟基化其7'-碳原子形成的代谢产物，具备显著的激素活性。

Butylparaben sodium 可通过干扰激素控制和 或破坏 RNA 及蛋白质合成来显著影响睾丸中的精子发生晚期。

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin/CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin/CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg/kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg/kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg/kg/day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromatase inhibitors, and fulvestrant). The prodrug tamoxifen is metabolized by the CYP2D6 enzyme to produce afimoxifene (4-hydroxytamoxifen) and endoxifen.

Etamestrol is a synthetic, steroidal estrogen described as an ovulation inhibitor or hormonal contraceptive

Ascr#7, an ascaroside-based hormonal compound, plays a significant role in nematode physiology. It is specifically expressed throughout the various stages of nematode development. Notably, ascarosides exhibit the capability to initiate the formation of dauer larvae, which are characterized by their long lifespan and exceptional stress resistance.