methicillin

Oxacillin sodium monohydrate (Stapenor monohydrate) 是一种抗生素，可研究耐药性葡萄球菌感染，类似 Flucloxacillin。

Methicillin sodium salt 是β-内酰胺抗生素，抑制参与肽聚糖合成的青霉素结合蛋白。

VP-4604是一种有效的抗耐甲氧西林金黄色葡萄球菌（MRSA）化合物。VP-4604对金黄色葡萄球菌展现出显著的抑制微生物生长的作用，MIC 为4-8μg mL。VP-4604抑制耐甲氧西林金黄色葡萄球菌的生长，其生长抑制率达到95%以上。

Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。

Linezolid (PNU-100766) 是恶唑烷酮类合成抗生素，抑制细菌蛋白质合成的起始阶段，具有抗感染作用。

Ceftobiprole medocaril (BAL5788) 是 Ceftobiprole 的前药。Ceftobiprole 是一种广谱的头孢菌素，对耐甲氧西林金黄色葡萄球菌具有活性。

Nafcillin sodium monohydrate (CL 8491) 是一种抗生素，是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。

Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg mL 和 0.25 μg mL。

Targocil 是一种磷壁酸生物合成的抑菌抑制剂，可抑制甲氧西林敏感金黄色葡萄球菌 (MSSA) 和耐甲氧西林金黄色葡萄球菌 (MRSA) 的生长，对于 MRSA 和 MSSA 的MIC90值都为 2 μg mL。

(-)-Corynoxidine 是一种源自 Stephania succifera 块茎的 AChE 抑制剂。 Corynoxidine 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌具有不同程度的抗菌活性。

6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱，它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。

Eperezolid (PNU-100592) 是一种在体外表现出良好抑制活性的恶唑烷酮类抗生素。

Sanguisorbigenin (Tomentosolic acid) 抑制耐甲氧西林金黄色葡萄球菌，是一种天然抗菌剂。

Toralactone 是从决明子中分离得到的，对耐甲氧西林金黄色葡萄球菌显示出抗菌作用。

2,3-Dehydrokievitone 是一种从刺桐属植物 Erythrina sacleuxii 中提取的一种异黄酮，具有抗菌活性，可通过降低α-溶血素表达来对抗耐甲氧西林金黄色葡萄球菌感染。

Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用，MIC 值都为 128 μg mL。

Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素，对甲氧西林耐受的金黄色葡萄球菌的MIC90值为 2 μg mL。

Continentalic acid 是来自 Aralia continentalis 的，对金黄色葡萄球菌的 MIC 约为 8-16 µg mL，包括对甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌标准菌株。

Methicillin is a narrow-spectrum beta-lactam antibiotic of the penicillin-like family, used to treat infections caused by susceptible gram-positive bacteria, in particular penicillase-producing organisms such as Staphylococcus aureus.

Methcillin sodium hydrate 是一种窄谱 β-内酰胺类抗生素，通过抑制青霉素结合蛋白 (penicillin-binding proteins,PBP) 发挥作用。Methcillin sodium hydrate 对青霉素耐药性的金黄色葡萄球菌Staphylococcus aureu 和表皮葡萄球菌Staphylococcus epidermidis 有活性。Methcillin sodium hydrate 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。

Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively). Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml). It generates cations that bind to and destabilize the bacterial cell wall to induce death.6 Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay. Formulations containing chlorhexidine have been used in antisept......

TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared with tunicamycin. 1.Price, N.P., Hartman, T.M., Li, J., et al.Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactamsJ. Antibiot. (Tokyo)70(11)1070-1077(2017)

VP-4509 是一种抗耐甲氧西林金黄色葡萄球菌 (MRSA) 剂 (MIC: 49.3 μM)。VP-4509 对革兰氏阴性细菌铜绿假单胞菌 (ATCC9027) 表现出高抗菌效果。

BO3482 is an antimicrobial compound and can inhibit the growth of methicillin-resistant Staphylococci (MIC90: 6.25 mg mL).

Pazufloxacin (T-3761)是氟喹诺酮类广谱抗生素。

Anti-MRSA agent 4 (compound 7a) 为针对耐甲氧西林金黄色葡萄球菌 (MRSA) 的革兰氏阳性菌强效选择性生长抑制剂，具有MIC≤ 0.26 µM的显著效力。此外，该化合物在HEK293细胞中未显示细胞毒性和溶血活性。

Antibacterial agent 86 (Compound A11) 活性较强，对耐甲氧西林金黄色葡萄球菌具有抑菌活性，MIC 值低至 0.00191 μg/mL，比市售抗生素泰妙菌素和瑞他莫林分别低 162 倍和 32 倍。

Ceftaroline fosamil hydrate acetate 是一种高效的头孢菌素类抗生素(antibiotic)，对多种病原体有广谱活性，特别是针对革兰氏阳性病原体，如耐甲氧西林金黄色葡萄球菌(MRSA)和耐多药肺炎链球菌，以及常见的革兰氏阴性微生物。此外，Ceftaroline fosamil hydrate acetate 在治疗复杂皮肤及皮肤结构感染(cSSSIs)和社区获得性肺炎(CABP)方面表现出显著的抗感染活性。

Antibacterial agent 136 (compound 3) 是恶二唑酮类抗生素。Antibacterial agent 136 对 Staphylococcus aureus(MRSA) 具有很高的抗菌效力，MIC50值为 0.8 μM。

Laburnetin 是一种异黄酮类抗菌剂 (antibacterial agent)。Laburnetin 对真菌、S. vesicarium 具有抗菌活性。Laburnetin 增强了耐甲氧西林 (Methicillin) 金黄色葡萄球菌 (MRSA) 菌株对甲氧西林的敏感性。Laburnetin 可用于控制栽培物种的虫害。

Anti-MRSA agent 2 (compound 14) 能够较好的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) (MIC: 0.098 μg ml)，对正常细胞的毒性相对较低。Anti-MRSA agent 2 能够较强的破坏细菌膜，并具有较好的与细菌基因组DNA 结合的能力。

Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus.

Antibacterial agent 98 (compound g37) 是口服有效的抗菌剂，可以抑制 Gyrase B 的 ATP 酶活性并削弱金黄色葡萄球菌 (S. aureus )的DNA 超螺旋。Antibacterial agent 98 不会诱导 MRSA (耐甲氧西林金黄色葡萄球菌 (S. aureus)) 的耐药性发展。

TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin . It is active against Gram-positive bacteria (MICs = 0.39-3.13 μg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 μg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 μg/ml).

Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-

CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse effects against mammalian cells or C. elegans development, survival, or reproduction.

Anti-MRSA agent 3 能够明显的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) 的活性 (MIC: 0.098 μg/ml)，并且对正常细胞毒性较低。Anti-MRSA agent 3 对细菌基因组 DNA 具有较高的结合亲和力，对细菌细胞壁和细胞膜具有较强的破坏能力。

Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S. aureus (MRSA; MIC = 3.12 µg ml).

Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus

Alopecurone A demonstrates potent inhibitory effects on MRP1, exhibits cytotoxic activity against DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) with IC50 values of 2.44 and 5.44 μg/mL, respectively, and possesses antibacterial activity against methicillin-resistant Staphylococcus aureus.

Parvodicin C2, a glycopeptide antibiotic derived from A. parvosata and part of the parvodicin complex, serves as a component of the A40926 antibiotic complex utilized as a precursor for synthesizing dalbavancin. It exhibits activity against methicillin-sensitive and methicillin-resistant strains of S. aureus, S. epidermidis, S. saprophyticus, S. hemolyticus, and E. faecalis.

Pristinamycin, 一种 Streptomyces pristinaespiralis 产生的口服活性链霉素样抗生素，由化学上不相关的两部分组成：Pristinamycin I (PI) 与 Pristinamycin II (PII)。该药物对包括耐甲氧西林金黄色葡萄球菌 (MRSA)、万古霉素耐药金黄色葡萄球菌 (VRSA) 和粪肠球菌 (VREF) 在内的多种抗生素耐药革兰氏阳性菌表现出强大活性。

Lynronne-2是抗菌肽，对革兰氏阳性细菌，包含MDR菌株具有活性（耐甲氧西林MRSA菌株MIC: 32-256 μg/mL）。该化合物亦对P. aeruginosa感染展现效用。

PSMα3 TFA 作为一种肽类化合物，主要用于诱导生成耐受性的树突细胞（DC），以应用于DC疫苗接种。该化合物能对TLR2和TLR4诱导的DC成熟过程进行调节，抑制促炎和消炎细胞因子的产生，降低抗原摄取，并影响人单核细胞来源DC的渗透和调节能力。此外，PSMα3 TFA 是耐甲氧西林金黄色葡萄球菌（MRSA）中最有毒株释放的关键毒素之一。

Garvicin KS（GakB）是由34个氨基酸组成的肽，与GakA和GakC共同构成细菌素GarKS。该肽不仅能抑制成纤维细胞活力和增殖，还表现出与GakA组合时的优异稳定性、抗菌效能以及对成纤维细胞作用。针对MSSA的抑制，Garvicin KS肽的MIC值显示GakB的活性最强，其次为GakC，GakA活性最低。

Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).

Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.

DHFR-IN-9（化合物8A）是一种二氢叶酸还原酶（DHFR）抑制剂，通过干扰细胞内嘌呤和胸苷酸的生物合成而影响细胞生长和增殖。该化合物对抗耐甲氧西林金黄色葡萄球菌（MRSA）ATCC 43300展现出显著的抑制效果（IC50=0.25 μg/mL），并在全身及大腿感染的小鼠模型中显示出抗感染能力（剂量：2.5 mg/kg，5 mg/kg；ip）。此外，DHFR-IN-9在乳腺癌小鼠模型中展示了超过紫杉醇（Y-B0015）的抗癌活性（剂量：2.5 mg/kg；ip；每3天1次）。

Chlorhexidine (Rotersept) 是一种抗菌剂和防腐剂。它可用于注射前、手术前或外伤后清洁皮肤。

Chlorhexidine dihydrochloride (NSC-185) 是一种消毒剂和局部抗感染剂，也用作漱口水以防止口腔菌斑。

Chlorhexidine digluconate 是一种广谱防腐剂和消毒剂，具有广谱抗菌活性，抑制革兰氏阳性菌和革兰氏阴性菌，可诱导细胞坏死和凋亡，可用于研究细菌感染。

Chlorhexidine diacetate (Bactigras) 是一种双胍类杀菌剂，能快速消灭革兰氏阳性菌和革兰氏阴性菌。它也用作漱口水以防止口腔菌斑。

Chlorhexidine acetate hydrate 是一种消毒剂和局部抗感染剂，也用作漱口水以防止口腔菌斑。