mog (89113), human

MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.

MOG (35-55), human, a constituent of central nervous system myelin, is distinguishable from mMOG (35-55) due to a proline-to-serine substitution at position 42. It possesses immunogenic properties and is partially cross-reactive with mMOG35–55. However, MOG (35-55), human does not induce encephalitogenic effects, and only elicits minimal clinical signs of EAE (experimental autoimmune encephalomyelitis) in comparison to the rodent peptide.

Myelin Oligodendrocyte Glycoprotein (MOG) peptide 是 MOG 的一种内源性肽段截取，存在于髓鞘的细胞外表面。当与抗原血清型HLA-DR2结合时，MOG peptide 在通过中脑动脉阻塞（MCAO）诱导的缺血性中风模型中，能减少皮层和纹状体梗死体积，降低管-角转测试中的感觉运动障碍，增加对新奇气味的探索时间，以及增加雌性（但不是雄性）小鼠对笼伴侣发出的呼叫持续时间。