npr 3

Atrial Natriuretic Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic peptide receptors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA ANP, brain natriuretic peptide NPPB BNP, and C-type natriuretic peptide NPPC CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Osteocrin was found to be a specific ligand to NPR3. NPR3 is necessary for Osteocrin to regulate femoral, tibial, and metatarsal bone elongation.

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA ANP, brain natriuretic peptide NPPB BNP, and C-type natriuretic peptide NPPC CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 54.0 kDa and the accession number is P17342.

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA ANP, brain natriuretic peptide NPPB BNP, and C-type natriuretic peptide NPPC CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.9 kDa and the accession number is P41740.