tonsillar lymphocyte ld78 b protein

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.

Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.7 kDa and the accession number is A2QEJ9.

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 19.2 kDa and the accession number is P32890.

Gasdermin-B Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.2 kDa and the accession number is Q8TAX9.

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Human adenovirus B serotype 11 (strain BC34) Fiber protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.6 kDa and the accession number is P35773.

Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Protein U22 (His) is expressed in in vitro E. coli expression system.

Binds and inhibits the conjugation of the ubiquitin-like G1P2 ISG15 protein to its target proteins. Since G1P2 ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2 PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2 PKR. Also binds poly(A) and U6 snRNA.

Influenza B (strain B Lee 1940) Nucleoprotein NP Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63.8 kDa and the accession number is P04665.

Trp B Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40-50 KDa and the accession number is P0A879.

Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its self-assembling nature.

HIV-1 (group M, subtype B, strain SHIV-89.6P) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.4 kDa and the accession number is O11407.

HIV-1 (group M, subtype B, isolate BAL) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.4 kDa and the accession number is Q03805.

Cathepsin B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A024R374.

Fetuin B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q9QXC1-1.

JAM-B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.7 kDa and the accession number is Q9JI59.

The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or reducing dietary fructose significantly reduces liver metastatic growth but has little effect on the primary tumor. Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by aldolase B (ALDOB) deficiency resulting in an inability to metabolize fructose. The toxic accumulation of intermediate fructose-1-phosphate causes multiple metabolic disturbances, including postprandial hypoglycemia, lactic acidosis, electrolyte disturbance, and liver kidney dysfunction.

Influenza B (B Brisbane 60 2008) Hemagglutinin HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is C0LT35.

NKG2D CD314 Protein, Human, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is P26718-1.

NKG2D CD314 Protein, Rhesus, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.3 kDa and the accession number is P61252.

Human metapneumovirus (strain HMPV Homo sapiens PER CFI0466 2010 B) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.6 kDa and the accession number is X4Y8Q3.

Influenza B (B Washington 02 2019) Hemagglutinin HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.6 kDa.

Influenza B (B Washington 02 2019) Nucleoprotein NP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 63 kDa.

Influenza B (B Utah 02 2012) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.1 kDa and the accession number is K0BY85.

Influenza B (B Utah 02 2012) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is K0BY85.

Influenza A H3N2 (A Perth 16 2009) Hemagglutinin HA-specific B cell probe Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58 kDa and the accession number is C6KNH7.

Influenza B (B PHUKET 3073 2013) Hemagglutinin HA0 Protein is expressed in Baculovirus insect cells. The predicted molecular weight is 61.7 kDa.

Influenza B (B Victoria 705 2018) Neuraminidase NA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.41 kDa.

Human respiratory syncytial virus (RSV) (B, strain 18537) Fusion glycoprotein F0 RSV-F Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.03 kDa and the accession number is P13843.

Human respiratory syncytial virus (RSV) (B, strain 18537) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.40 kDa and the accession number is P20896.

SARS-CoV-2 B.1.617.1 Spike S1+S2 trimer Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 136.55 kDa and the accession number is A0A6G7K2L4.

SARS-CoV-2 B.1.1.529 (Omicron) Spike S1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76.48 kDa and the accession number is A0A6G7K2L4.

Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Flagellin B(flaB) Protein, Campylobacter jejuni, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 61.6 kDa and the accession number is Q46114.

Car b 1 isoforms 1A and 1B Protein, Carpinus betulus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P38949.

CS6 fimbrial subunit B Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli.

Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus. Human adenovirus B serotype 3 Hexon protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.7 kDa and the accession number is P36849.

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.; Core component of multiple cullin-RING-based ECS (ElonginB C-CUL2 5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin RBX1 modules that activate E2 ubiquitination enzymes. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.

Rhesus cytomegalovirus (RhCMV) (strain 68-1) Glycoprotein B gB Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.0 kDa and the accession number is P89053.

Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin-3 LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. Staphopain B Protein, S. aureus, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 46.9 kDa and the accession number is Q99V46.

Suid herpesvirus 1 (SuHV-1) Glycoprotein B gB Protein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 11.8 kDa and the accession number is P08355.

Defense against chitin-containing fungal pathogens.

Endothelin B Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.5 kDa and the accession number is P24530-1.

Human cytomegalovirus (HCMV) Glycoprotein B gB Protein is expressed in HEK293 mammalian cells. The predicted molecular weight is 92 kDa and the accession number is P13201.

Influenza B (B Malaysia 2506 2004) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is C0RVT0.

Influenza B (B Florida 4 2006) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is B1AG46.

Human cytomegalovirus (HCMV) Glycoprotein B gB Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 93.2 kDa and the accession number is P13201.

Fetuin B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41.7 kDa and the accession number is Q9UGM5-1.

PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing.

E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregative Shiga-toxin–producing E. coli O104:H4, producing extended-spectrum beta-lactamase. The toxin has two subunits—A and B. E. Coli STX2B is the B subunit. It is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide. Following this, the A subunit is internalised and cleaved into two parts. Stx2 has been found to be approximately 400 times more toxic (as quantified by LD50 in mice) than Stx-1. The Stx1 and Stx2 B subunits form a pentameric structure that binds to globotriaosylceramide receptors on eukaryotic cells and promotes endocytosis.