acat

Indacaterol 是一种超长效β-肾上腺素受体激动剂。

Dibutyl sebacate (Dibutyl decanedioate) 是一种常作为塑料生产中的增塑剂的癸二酸二丁酯。

Saracatinib (AZD0530) 是一种有效的 Src 抑制剂，抑制 c-Src、Lck、c-YES、Lyn、Fyn、Fgr 和 Blk 的 IC50值在 2.7 到 11 nM 之间，对其他酪氨酸激酶具有选择性。

TMP-153 是一种新型高效的 ACAT 抑制剂，对动物肠道和肝脏 ACAT 的 IC50 值为 5-10 nM。TMP-153  具有降胆固醇作用，可抑制大鼠和仓鼠的胆固醇吸收并降低血浆胆固醇。

Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂，可用于研究由于高脂带来的疾病。

Monatepil 2maleate 是一种具有口服活性的 Ca2+-通道 拮抗剂和 ACAT 抑制剂，具有 α（1）-肾上腺素能受体阻断活性和抗心律失常特性，可抑制血管收缩。Monatepil 2maleate 可用于研究动脉粥样硬化。

CL 277082 (Ddpmhu) 是一种酰基辅酶A：胆固醇O-酰基转移酶抑制剂，抑制肉芽肿组织 ACAT 活性。

Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。

Monatepil maleate (AJ-2615 maleate) 是一种具有口服活性的 Ca2+-通道和α1-肾上腺素受体拮抗剂，也是非竞争性肝酰辅酶A：胆固醇酰基转移酶（ACAT）抑制剂，具有抗高血压活性。Monatepil maleate 可用于研究高脂血症和动脉粥样硬化。

Odanacatib 是组织蛋白酶K（人 兔）的选择性抑制剂，IC50分别为0.2 nM 和 1 nM。

PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤，包括在内吞和分泌途径中发现的步骤。

RP 70676 是ACAT 抑制剂，抑制大鼠和兔子中 ACAT 的IC50分别为 25 和 44 nM。

VULM 1457 是有效的胆固醇酰基转移酶抑制剂，具有显著的降血脂活性，并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌，并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。

YM17E 是一种 ACAT 抑制剂，在体外兔肝微粒体中的 IC50 为 44 nM。

YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。

RP-64477 是有效的胆固醇酯化酶酰基辅酶 A：胆固醇 O-酰基转移酶 (ACAT) 抑制剂。

SR144528 是 CB2 受体的拮抗剂 (Ki = 0.6 nM) 并抑制微粒体 ACAT 活性 (IC50 = 3.6 μM)。

Lateritin (Bassiatin) 是一种酰基辅酶 A，是胆固醇酰基转移酶 (ACAT) 抑制剂和来自赤霉属菌丝饼的血小板聚集抑制剂。 Bassiatin 是 (3S,6R) 异构体。

Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂，对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。

Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮，是一种有效且非竞争性的酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂，抑制大鼠肝脏微粒体 ACAT 的IC50为 24.6 μM。

Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA：胆固醇酰基转移酶（ACAT）有抑制作用，其 IC50 值为 3 μM。

ACAT-IN-1 cis isomer是一种有效的 ACAT 抑制剂（IC50：100 nM），可用于研究免疫系统相关疾病。

ACAT-IN-10 is an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. It inhibits NF-κB mediated transcription with a weak activity.

ACAT-IN-5 (example 19) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By inhibiting ACAT, this compound effectively suppresses the transcription mediated by NF-κB.

ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription.

ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription.

ACAT-IN-3, a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), effectively suppresses NF-κB dependent transcription.

ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB.

ACAT-IN-10 dihydrochloride is a compound that serves as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT).ACAT-IN-10 dihydrochloride effectively hampers NF-κB mediated transcription, albeit to a lesser extent.

ACAT-IN-4 (Example 208) is a chemical compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). Additionally, ACAT-IN-4 effectively inhibits the transcription process mediated by NF-κB.

ACAT-IN-8 (example 206) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation. This compound also possesses the ability to inhibit transcription mediated by NF-κB.

ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription.

ACAT-IN-4 hydrochloride (Example 208) is a hydrochloride salt of a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively hinders NF-κB mediated transcription.

Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774.

Dutacatib 是一种 SARS-CoV-2 3CLpro 和组织蛋白酶 K (cathepsin K) 的抑制剂，表现出抗病毒活性，并可改善癌症导致的骨病。

Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in human tissue, while in vivo studies on cynomolgus monkeys further validate its efficacy in reducing bone resorption.

Dipentyl sebacate is a biochemical.

Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor.

Piperazine sebacate has anthelminthic activity. it be studie for therapy of trichocephalosis.

Cupric sebacate is a biochemical.

Indacaterol xinafoate is an ultra-long-acting beta-adrenoceptor agonist.

Cadmium sebacate is a biochemical.

Indacaterol fumarate is an ultra-long-acting beta-adrenoceptor agonist.

Bis(2-butoxyethyl) sebacate is a biochemical.

Dibenzyl sebacate is a biochemical.

Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist.

Bis(2-ethylhexyl) sebacate is used as a plasticizer in preparing ion-selective electrodes. It is an important raw material and intermediate used in organic synthesis, agrochemicals, pharmaceuticals and dyestuff fields.

Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.