b-10

SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物，可以抑制 DNA 和 RNA 合成 (IC50=0.077 1.3 μM)。SN-38 具有抗肿瘤活性，可以诱导细胞自噬。

Rhodamine B (Brilliant Pink B) 是荧光染料，常用于染色纺织品、肥皂、纸张、皮革和药品。

Rosiridin (6'-O-Deacetylrosiridoside C) 能够抑制 MAO A 和 MAO B，有潜在的抑郁症和老年性痴呆作用。它在 10 μM 时对 MAO B 的抑制率为 83.8% (pIC50=5.38)。

Isorubrofusarin-6-O-β-gentiobioside 来源于 Cassia obtusifolia Linn 种子，对 AChE 和 BACE1 具有良好的抑制活性。

Neuromedin B 是由10个氨基酸组成的神经肽，属于蛙肽家族，为铃蟾肽相关肽。

β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) 是一种雌二醇代谢物。

7,8,9-Trimethoxy-10H-1,3-dioxolo[4,5-b]xanthen-10-one 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125216。

10-Hydroxyaloin B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126013。

7-Xylosyl-10-deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) 是一种来自红豆杉科植物东北红豆杉的紫杉醇衍生物，具有抗肿瘤活性，可用于合成紫杉醇。

10-O-Methylprotosappanin B 是一种存在于从哥伦比亚北部采集的巴西血霉中的原皂苷类化合物。

16-epiLatrunculin B, a stereoisomer of the actin polymerization inhibitor latrunculin B, was initially isolated from the Red Sea sponge N. magnifica. At concentrations of 5-10 µg/ml, it disrupts microfilament activity in actin disruption assays and exhibits cytotoxic effects on mouse KA31T and NIH3T3 tumor cells, with GI50 values of 1 and 4 µg/ml, respectively. Furthermore, it shows antiviral activity against herpes simplex type 1 virus, with an ED50 of 1 µg/ml.

Tanzawaic acid B ((+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E) 可从Penicillium citrinum中分离提取，主要具有超氧阴离子产生的抑制作用。

Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.

Neohelmanthicin B，一种从Thapsia garganica提取的苯丙素，对EL4、S180和MCF7细胞系展现出显著的细胞毒性作用，其IC50值分别为10、5和12 μM。

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0 G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Lentztrehalose B, a microbial disaccharide metabolite isolated from Lentzea, exhibits a range of biological activities. At a concentration of 100 µM, it demonstrates antioxidant properties in an oxygen radical absorbance capacity (ORAC) assay. Furthermore, Lentztrehalose B at 10 mM inhibits porcine kidney trehalase, an enzyme involved in trehalose metabolism. Additionally, it induces autophagy in MeWo melanoma and OVK18 ovarian cancer cells when applied at 100 mM.

Sonnerphenolic B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5426，CAS号为 1627516-10-2。

Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997). Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3 References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997).

Ikarisoside B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126358，CAS号为 113558-10-4。

Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytochemistry 28(10), 2803-2806 (1989). Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives. References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytochemistry 28(10), 2803-2806 (1989).

Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the growth factor induced tube formation

Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2 M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

Arsenobetaine, an organoarsenical and compatible solute, is discovered in numerous marine animals like lobsters and crabs, and terrestrial organisms such as earthworms and lichens. It protects against B. subtilis cell death caused by high osmolarity or extreme temperatures at 1 mM concentration. Notably, arsenobetaine exhibits non-toxicity to mice with an LD50 of 10 g/kg.

Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC50 value of 2.6 x 10(-5) M.