congestive heart failure

(±)-Prenalterol (H 80 62) 是一种新的心脏选择性正性肌力化合物，是β-2-和β-1-肾上腺素受体的激动剂，可用于研究慢性充血性心力衰竭。

Levocarnitine propionate hydrochloride (ST-261) 可用于肾功能恶化，充血性心脏衰竭，间歇性跛行等疾病的研究。

Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。

Quinapril hydrochloride (PD-109452-2) 是一种血管紧张素转化酶(ACE) 抑制剂的原药。

Captopril (SA333) 是一种含巯基的，具有口服活性的血管紧张素转换酶(ACE)抑制剂 ，IC50=0.025 μM，广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂，IC50=7.9 μM。

(Rac)-Naxifylline 可用于研究充血性心力衰竭。

(Rac)-Daglutril (SLV 306 acetic acid) 是 Daglutril 的消旋体。Daglutril 是一种口服活性的混合中性内肽酶 内皮素转化酶抑制剂，正在开发用于治疗原发性高血压和充血性心力衰竭。

PD-118057 是一种有效的乙醚相关(hERG)钾通道激活剂，对 hERG 不显示活性。PD-118057 通过激活 hERG 通道来抑制膜的兴奋性变化。PD-118057预防和逆转 QT 间期延长，是治疗遗传性或获得性长 QT 综合征和充血性心力衰竭的延迟复极的潜在化合物。

Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞，可抗登革病毒感染， IC50为0.19 μM。

Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。

Enoximone 是一种选择性的，具有口服活性的磷酸二酯酶 III 抑制剂，也是正性肌力血管舒张剂。它通过抑制 cGMP 抑制的 PDE 来诱导血管舒张并增加细胞内 cAMP 水平。它还表现出 PDE4抑制作用，对心肌 PDE4A 的 IC50为 21.1 μM。它用于充血性心力衰竭的研究，并具有支气管扩张，抗哮喘和抗炎作用。

Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，可抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常，并在研究慢性心房颤动时控制心室率。

Digoxigenin, a therapeutic drug belonging to the group of cardiac glycosides, is widely used in the management of congestive heart failure and other cardiac diseases

Rolofylline (KW-3902) 是一种具有选择性腺苷 A1 受体拮抗剂，可用于研究急性充血性心力衰竭和肾功能障碍，可用与研究神经退行性疾病。

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。

Furosemide sodium (Frusemide Sodium) 是 Na+ K+ 2Cl- (NKCC)，NKCC1 和 NKCC2 共转运蛋白的有效的和具有口服活性抑制剂。Furosemide sodium 也是 GABAA 受体拮抗剂，对含 α6 受体的选择性是含 α1 受体的 100 倍。Furosemide sodium 用作利尿试剂，用于充血性心力衰竭，高血压和水肿的研究。

Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。

Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。

Levosimendan (OR1259) 是一种钙增敏剂，通过以钙依赖性方式与心肌肌钙蛋白 C 结合，增加肌细胞对钙的敏感性来发挥其作用，可治疗急性失代偿性充血性心力衰竭。

Epoprostenol sodium (Prostaglandin I2 sodium salt) 是短效血管稀释剂，是一种合成前列环素，可用于研究肺动脉高压和充血性心力衰竭。

Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness.

Imazodan hydrochloride (CI-914 HCl) 是一种强效的选择性 III 型磷酸二酯酶抑制剂，用于治疗慢性充血性心力衰竭。

Nolomirole is a dopamine receptor agonist that reduces symptoms of congestive heart failure caused by monoclinine.

Cilazapril Monohydrate (Justor) 是一种血管紧张素转化酶抑制剂，能够作用于高血压和充血性心力衰竭的研究。

Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.

Benzofurodil is cardiotonic used for the chronic treatment of congestive heart failure.

Captopril (SQ 14225) hydrochloride 是一种含巯基的口服活性血管紧张素转换酶(ACE)抑制剂，IC50值为0.025 μM，已广泛应用于高血压和充血性心力衰竭的研究。Captopril hydrochloride 也是 NDM-1抑制剂，IC50值为 7.9 μM。

CK 2289 is an inhibitor of type III cyclic 3'5' -adenosine monophosphate phosphodiesterase with potential use in the treatment of congestive heart failure.

Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE). It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.

Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hypertension and edema often due to cong

NP-252 is a calcium channel antagonist potentially for the treatment of angina pectoris and congestive heart failure.

A 58365 B, an angiotensin converting enzyme (ACE) inhibitor isolated from Streptomyces chromofuscus, is used for the treatment of congestive heart failure and hypertension.

Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.

BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.

Neuropeptide Y (18-36) (porcine) 是一种与Neuropeptide Y(NPY)心脏受体进行竞争性拮抗的化合物。该化合物通过浓度依赖的方式，抑制I-NPY与心室膜的结合，具有IC50值158 nM和Ki值140 nM。Neuropeptide Y (18-36) (porcine) 主要用于充血性心力衰竭的研究。

PD 113413 is a metabolite of quinapril, an angiotensin-converting enzyme inhibitor for the treatment of hypertension and congestive heart failure.

Amisometradine is a diuretic which may be used in the treatment of congestive heart failure.

GRK2 Inhibitor 2 (Compound 8h) 作为一种高效的抑制剂，对GRK2有显著的抑制活性（IC50: 19 nM），同样对Aurora-A也表现出抑制作用（IC50: 137 nM）。该化合物能增强GRK2过表达的HEK293细胞中β-AR介导的cAMP积累。此外，GRK2 Inhibitor 2适用于充血性心力衰竭（HF）的相关研究。

NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.

Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme inhibitor used in the treatment of congestive heart failure and hypertension.

Spirapril (SCH 33844) hydrochloride 是血管紧张素转换酶 (ACE) 的有效抑制剂，是一种口服具有活力的螺普利拉前药。Spirapril hydrochloride 能够竞争性地与 ACE 结合，阻断血管紧张素I 向血管紧张素 II 的转化，表现出降压活性。Spirapril hydrochloride 能够用于研究高血压、充血性心力衰竭。

CK 3197 is a selective positive inotropic agent for the treatment of congestive heart failure. It has hemodynamic and myocardial energetic effects.

Trandolapril (RU44570) hydrochloride 是一种非巯基前体化合物，水解为活性双乙酰 (Trandolapril hydrochlorideat)。Trandolapril hydrochloride 是一种口服具有活力的血管紧张素转换酶 (ACE) 抑制剂。Trandolapril hydrochloride 能够高血压和充血性心力衰竭及心肌梗死的研究。

GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the treatment of pulmonary edema associated with congestive heart failure.

OPC 18692 is a metabolite of Vesnarinone, a positive inotropic drug developed for congestive heart failure.

A 58365 A, an angiotensin converting enzyme (ACE) inhibitor isolated from Streptomyces chromofuscus, is used for the treatment of congestive heart failure and hypertension.

Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.

Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure. Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure.