propagation

Arbidol (Umifenovir) 是一种具有口服活性广谱抗病毒化合物，属于融合抑制剂，可与 SARS-CoV-2 刺突蛋白相互作用。Arbidol 对多种冠状病毒显示出抑制活性。Arbidol 具有抗炎抗氧化活性，可用于研究浓度感染。

Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。

SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。

Oxybuprocaine hydrochloride (Oxybuprocaine HCl) 是可逆的钠通道阻断剂，可防止角膜，结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科与耳鼻喉科。

SID 26681509 是可逆的，竞争性的人组织蛋白酶 L 选择性抑制剂，IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖，IC50为15.4 μM，抑制Leishmania major，IC5012.5 μM。

SID 26681509 quarterhydrate 是可逆的、有效的、选择性的、竞争性的人组织蛋白酶 L (human cathepsin L) 抑制剂 (IC50: 56 nM)。SID 26681509 quarterhydrate 能够抑制Plasmodium falciparum 的体外繁殖 (IC50: 15.4 μM)，并抑制Leishmania major (IC50: 12.5 μM)，且不抑制组织蛋白酶 G 的活性。

Antibacterial agent 116 是一种含二苯甲酮的水杨酰苯胺类化合物。Antibacterial agent 116 能抑制肽聚糖的形成而具有较强的抗菌活性。Antibacterial agent 116 可作为光亲和探针标记 Acinetobacter baumannii 的青霉素结合蛋白 (PBP1b)，干扰肽聚糖链的生长，阻断其增殖。

Brilliant green, a cationic dye, is utilized for coloring silk and wool. Additionally, it halts the propagation of mold, intestinal parasites, and fungus, proving effective against Gram-positive bacteria [1] [2].

Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM） and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e

ProTx-II TFA是选择性作用于Nav1.7钠通道的阻滞剂，具有0.3 nM的IC50值，选择性比其他钠通道亚型高出至少100倍。该化合物抑制钠离子通道，通过减少通道电导及使激活电压向更正的电位移动，从而阻断痛觉感受器中动作电位的传导。

ARC19499 是一种核酸适配体， 与组织因子通路抑制剂(TFPI)特异性结合，阻断 TFPI 对factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A 和B 血浆中的凝血酶生成，并恢复凝血。

WW-781 is used to measure action potential propagation in the heart.

VGD020 is a CD4 and sortilin inhibitor. It displayed activity for sortilin down-modulation and reduction of progranulin-induced breast cancer stem cell propagation.

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med.Chem.Lett. 3 106 PMID:24900436 |Fukushima et al (2016) Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107 1422 PMID:27461445 |Giordani et al (2016) The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells. Oncotarget 7 55313 PMID:27486815

Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E. coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. Phosphatidylethanolamines (soy) is a mixture of phosphatidylethanolamines isolated from soy with various fatty acyl groups at the sn-1 and sn-2 positions.