(S)-Sitagliptinphosphate, the less active S-enantiomer of Sitagliptinphosphate, is a high-potency inhibitor of DPP4. It exhibits an IC50 of 19 nM in Caco-2 cell extracts.
Metformin hydrochloride mixture with sitagliptinphosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.