infarction

D-GsMTx4 TFA 是一种具有选择性的蜘蛛毒液肽，是一种TRPC1 / 6和Piezo2抑制剂，可抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道 （MSCs），阻断阳离子选择性的拉伸激活通道 （SAC），减弱溶血磷脂酰胆碱 （LPC） 诱导的星形胶质细胞毒性和小胶质细胞反应性。D-GsMTx4 TFA 在小鼠缺血/再灌注模型中预防心肌梗死，可用于鉴定兴奋性 MSC 在正常生理学和病理学中的作用。

Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。 它抑制食物摄入，抑制空肠收缩，并减少体重增加。

Lqvtdsglyrcviyhpp TFA 是一种由17个氨基酸组成的多肽，是可穿透血脑屏障的触发受体1 (TREM-1) 抑制剂，具有潜在的抗癌活性，可用于研究皮肤癌和胰腺癌。

Delcasertib acetate 是一种选择性 δ 蛋白激酶C (δPKC) 抑制剂，可用于研究急性心肌梗死和疼痛。

Delcasertib (KAI-9803) hydrochloride 是有效，选择性的 δ 蛋白激酶 C (δPKC) 抑制剂。Delcasertib (KAI-9803) hydrochloride 可改善急性心肌梗死动物模型的缺血再灌注损伤。

SDF-1α (human) 是一种能够与CXCR4受体相结合的单核细胞趋化剂，它在心肌梗死模型中的干细胞归巢、维持、生存、增殖、心肌细胞修复、血管形成以及心室重构过程扮演关键角色。SDF-1α (human) 常用于心血管病研究。

Adrenomedullin (AM) (1-12), human, is a peptide with the sequence Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg. Adrenomedullin (AM) (1-12), human, was initially identified as a vasodilator, and as such, it has the ability to relax vascular tone. Other

TRPC1 6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia reperfusion model. Resistant to proteolytic digestion.

TC 14012是一种化学肽模拟的拮抗剂，针对趋化因子(C-X-C motif)受体4（CXCR4；IC50 = 2.9 nM）和CXCR7激动剂。它能在表达CXCR7的HEK293T细胞中诱导β-arrestin招募（EC50 = 350 nM）。TC 14012可减少HIV在MT-4细胞中的细胞病理效应（EC50 = 0.4 nM），并以CXCR4依赖的方式抑制HIV在体外进入（IC50 = 19.3 nM）。它还能抑制由趋化因子(C-X-C motif)配体12（CXCL12）在MDA-MB-231乳腺癌细胞和人脐静脉内皮细胞（HUVECs）中诱导的迁移，当使用浓度范围从10到1,000 nM时。在通过左前降（LAD）冠状动脉结扎诱导的急性心肌梗死小鼠模型中，TC 14012（10 mg/kg）能减少梗死面积。

Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 19931. AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body2. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system used3. Other effects of AM include increasing the tolerance of cells to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the potential of cancerous cells to extend their blood supply and cause cell proliferation.

LQVTDSGLYRCVIYHPP (LP17) 为髓系细胞表达之触发受体 1 (TREM-1) 抑制性肽类化合物，能有效减轻缺血引发的梗塞及神经元损害，并可渗透大脑，阻断TREM-1。